Gorniak Stacey L, Wagner Victoria E, Vaughn Kelly, Perry Jonathan, Cox Lauren Gulley, Hernandez Arturo E, Pollonini Luca
University of Houston, Department of Health and Human Performance, Houston, Texas, United States.
University of Houston, Department of Psychology, Houston, Texas, United States.
Neurophotonics. 2020 Jul;7(3):035007. doi: 10.1117/1.NPh.7.3.035007. Epub 2020 Sep 2.
: Deficits in sensorimotor function in persons with type II diabetes mellitus (PwDM) have traditionally been considered a result of peripheral nerve damage. Emerging evidence has suggested that factors outside of nerve damage due to type II diabetes mellitus, such as impaired hemodynamic function, contribute significantly to both sensory and motor deficits in PwDM. : The focus of the current study was to evaluate functional cortical hemodynamic activity during sensory and motor tasks in PwDM. : Functional near-infrared spectroscopy was used to monitor oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) across the cortex during sensory and motor tasks involving the hands. : Decline in HbO across sensory and motor regions of interest was found in PwDM with simultaneous deficits in manual motor tasks, providing the first evidence of functional cortical hemodynamic activity deficits relating to motor dysfunction in PwDM. Similar deficits were neither specifically noted in HbR nor during evaluation of sensory function. Health state indices, such as , blood pressure, body mass index, and cholesterol, were found to clarify group effects. : Further work is needed to clarify potential sex-based differences in PwDM during motor tasks as well as the root of reduced cortical HbO indices but unchanged HbR indices in PwDM.
传统上认为，II型糖尿病患者（PwDM）的感觉运动功能缺陷是外周神经损伤的结果。新出现的证据表明，II型糖尿病导致的神经损伤之外的因素，如血流动力学功能受损，对PwDM的感觉和运动缺陷有显著影响。本研究的重点是评估PwDM在感觉和运动任务期间的功能性皮质血流动力学活动。在涉及手部的感觉和运动任务期间，使用功能性近红外光谱来监测整个皮质的氧合血红蛋白（HbO）和脱氧血红蛋白（HbR）。在手动运动任务同时存在缺陷的PwDM中，发现感兴趣的感觉和运动区域的HbO下降，这为PwDM中与运动功能障碍相关的功能性皮质血流动力学活动缺陷提供了首个证据。在HbR中未特别注意到类似缺陷，在感觉功能评估期间也未发现类似缺陷。发现健康状态指标，如 、血压、体重指数和胆固醇，可阐明组间效应。需要进一步开展工作，以阐明PwDM在运动任务期间潜在的基于性别的差异，以及PwDM中皮质HbO指数降低但HbR指数不变的根源。
