Department of Health and Human Performance, University of Houston, Houston, TX, United States of America.
Department of Pain Medicine Research, University of Texas M.D. Anderson Cancer Center, Houston, TX, United States of America.
PLoS One. 2020 Nov 12;15(11):e0242199. doi: 10.1371/journal.pone.0242199. eCollection 2020.
Recent evidence of significant sex-based differences in the presentation of Type 2 Diabetes Mellitus (DM) and its complications has been found in humans, which may contribute to sex-based differences in reduced functionality and quality of life. Some functionality, such as tactile function of the hands, has significant direct impact on quality of life. The purpose of the current study was to explore the impact of DM and sex on tactile function, with consideration of variability in health state measures.
A case-control single time point observational study from 2012-2020 in an ethnically diverse population-based community setting. The sample consists of 132 adult individuals: 70 independent community dwelling persons with DM (PwDM) and 62 age- and sex-matched controls (42 males and 90 females in total). The Semmes-Weinstein monofilament test was used to evaluate tactile sensation of the hands.
Tactile sensation thresholds were adversely impacted by sex, age, degree of handedness, high A1c, diagnosis of DM, and neuropathy. Overall, strongly right-handed older adult males with poorly controlled DM and neuropathy possessed the poorest tactile discrimination thresholds. When self-identified minority status was included in a secondary analysis, DM diagnosis was no longer significant; negative impacts of age, neuropathy, degree of handedness, and high A1c remained significant.
The data indicate significant impacts of male sex, age, degree of handedness, self-identified minority status, and metabolic health on the development of poor tactile sensation. This combination of modifiable and non-modifiable factors are important considerations in the monitoring and treatment of DM complications.
最近在人类中发现了 2 型糖尿病（DM）及其并发症表现方面存在显著的性别差异的证据，这可能导致性功能和生活质量降低方面存在性别差异。一些功能，如手部的触觉功能，对生活质量有重大的直接影响。本研究的目的是探讨 DM 和性别对触觉功能的影响，同时考虑健康状况测量的变异性。
这是一项 2012 年至 2020 年在种族多样化的社区环境中进行的病例对照单时间点观察性研究。该样本由 132 名成年个体组成：70 名独立居住在社区的 DM 患者（PwDM）和 62 名年龄和性别匹配的对照者（总共 42 名男性和 90 名女性）。使用 Semmes-Weinstein 单丝试验评估手部触觉。
触觉感觉阈值受到性别、年龄、手的惯用程度、高 A1c、DM 诊断和神经病变的影响。总体而言，控制不佳且患有神经病变的强右利手老年男性具有最差的触觉辨别阈值。当在二次分析中纳入自我认定的少数族裔地位时，DM 诊断不再具有显著性；年龄、神经病变、手的惯用程度和高 A1c 的负面影响仍然显著。
数据表明男性性别、年龄、手的惯用程度、自我认定的少数族裔地位和代谢健康状况对触觉感觉不良的发展有显著影响。这些可改变和不可改变的因素的组合是 DM 并发症监测和治疗中的重要考虑因素。
