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2020年美国临床肿瘤学会亮点:慢性淋巴细胞白血病治疗的最新进展

Highlights from ASCO 2020: updates on the treatment of chronic lymphocytic leukemia.

作者信息

Dolan S, Christofides A, Doucette S, Shafey M

机构信息

Dalhousie University, St. John, NB.

impact Medicom Inc., Toronto, ON.

出版信息

Curr Oncol. 2020 Aug;27(4):e420-e432. doi: 10.3747/co.27.7009. Epub 2020 Aug 1.

DOI:10.3747/co.27.7009
PMID:32905290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7467799/
Abstract

Because of the global coronavirus pandemic, the 2020 annual scientific meeting of the American Society of Clinical Oncology took place virtually, 29-30 May. At the meeting, results from key studies about the treatment of chronic lymphocytic leukemia (cll) were disseminated. Studies examined the efficacy and safety of ibrutinib, acalabrutinib, zanubrutinib, and venetoclax as monotherapy or in combination with novel agents for patients with treatment-naïve and relapsed or refractory cll. Our meeting report describes the foregoing studies and presents interviews with investigators and commentaries by Canadian hematologists about potential effects on Canadian practice.

摘要

由于全球冠状病毒大流行,美国临床肿瘤学会2020年年度科学会议于5月29日至30日以线上形式举行。会议上公布了关于慢性淋巴细胞白血病(CLL)治疗的关键研究结果。这些研究考察了伊布替尼、阿卡替尼、泽布替尼和维奈克拉作为单药治疗或与新型药物联合用于初治、复发或难治性CLL患者的疗效和安全性。我们的会议报告描述了上述研究,并展示了对研究人员的采访以及加拿大血液学家对其对加拿大临床实践潜在影响的评论。

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本文引用的文献

1
ASCEND: Phase III, Randomized Trial of Acalabrutinib Versus Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia.ASCEND:阿卡替尼对比伊布替尼联合利妥昔单抗或苯达莫司汀联合利妥昔单抗治疗复发或难治性慢性淋巴细胞白血病的 III 期随机试验。
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2
Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial.阿卡替尼联合或不联合奥滨尤妥珠单抗对比苯丁酸氮芥联合奥滨尤妥珠单抗治疗初治慢性淋巴细胞白血病(ELEVATE TN):一项随机、对照、III 期临床试验。
Lancet. 2020 Apr 18;395(10232):1278-1291. doi: 10.1016/S0140-6736(20)30262-2.
3
Review of Bruton tyrosine kinase inhibitors for the treatment of relapsed or refractory mantle cell lymphoma.布鲁顿酪氨酸激酶抑制剂治疗复发或难治性套细胞淋巴瘤的研究进展。
Curr Oncol. 2019 Apr;26(2):e233-e240. doi: 10.3747/co.26.4345. Epub 2019 Apr 1.
4
Randomized trial of ibrutinib vs ibrutinib plus rituximab in patients with chronic lymphocytic leukemia.随机对照试验:伊布替尼对比伊布替尼联合利妥昔单抗治疗慢性淋巴细胞白血病患者。
Blood. 2019 Mar 7;133(10):1011-1019. doi: 10.1182/blood-2018-10-879429. Epub 2018 Dec 7.
5
Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial.伊布替尼联合奥滨尤妥珠单抗与苯丁酸氮芥联合奥滨尤妥珠单抗一线治疗慢性淋巴细胞白血病(ILLUMINATE):一项多中心、随机、开放标签、III 期临床试验。
Lancet Oncol. 2019 Jan;20(1):43-56. doi: 10.1016/S1470-2045(18)30788-5. Epub 2018 Dec 3.
6
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Clin Cancer Res. 2017 Jul 15;23(14):3734-3743. doi: 10.1158/1078-0432.CCR-16-1446. Epub 2016 Dec 29.
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Lancet. 2016 Feb 20;387(10020):770-8. doi: 10.1016/S0140-6736(15)00667-4. Epub 2015 Dec 7.