Ontario Health (Cancer Care Ontario).
Dalla Lana School of Public Health, University of Toronto.
Curr Oncol. 2020 Aug;27(4):e395-e398. doi: 10.3747/co.27.6039. Epub 2020 Aug 1.
Colorectal cancer is one of the most common cancers in Ontario and imposes a high burden on many Indigenous populations. There are two aims for this short communication: ■ Highlight colorectal risk factor findings from a population-based case-control study■ Highlight trends and challenges of colorectal cancer research in Indigenous populations in Ontario.
Prevalences of cigarette smoking, obesity, fruit and vegetable consumption, and family history of colorectal cancer were estimated using the Indigenous identifier in the Ontario Familial Colon Cancer Registry for 1999-2007 and then compared for cases and controls using age-adjusted odds ratios (ors) with 95% confidence intervals (cis).
The registry search identified 66 Indigenous cases and 23 Indigenous controls. Cigarette smoking (or: 1.88; 95% ci: 0.63 to 5.60) and obesity (or: 2.16; 95% ci: 0.72 to 6.46) were higher in cases, but not statistically significantly so.
Findings were consistent with previous literature describing Indigenous populations. A small sample size and poor Indigenous identification questions make it challenging to comprehensively understand cancer risk factors and burden in Indigenous populations.
结直肠癌是安大略省最常见的癌症之一，给许多原住民群体带来了沉重负担。本简讯有两个目的： ■ 强调基于人群的病例对照研究中结直肠癌的风险因素发现；■ 强调安大略省原住民人群结直肠癌研究的趋势和挑战。
利用安大略家族结直肠癌登记处的原住民标识符，估算了 1999-2007 年期间的吸烟、肥胖、水果和蔬菜摄入以及结直肠癌家族史的流行率，然后使用年龄调整比值比（OR）及其 95%置信区间（CI），对病例和对照进行比较。
登记处搜索发现了 66 例原住民病例和 23 例原住民对照。病例组中吸烟（OR：1.88；95%CI：0.63 至 5.60）和肥胖（OR：2.16；95%CI：0.72 至 6.46）的比例较高，但无统计学意义。
这些发现与之前描述原住民人群的文献一致。样本量小且原住民身份识别问题严重，使得全面了解原住民人群的癌症风险因素和负担具有挑战性。
