Amakawa Masami, Gunawardana Soneli, Jabbour Alexy, Hernandez Alan, Pasos Chase, Alameh Saleem, Martchenko Shilman Mikhail, Levitin Anastasia
Henry E. Riggs School of Applied Life Sciences, Keck Graduate Institute, Claremont, California 91711, United States.
ACS Omega. 2020 Aug 18;5(34):21929-21939. doi: 10.1021/acsomega.0c03207. eCollection 2020 Sep 1.
Of the numerous infectious diseases afflicting humans, anthrax disease, caused by , poses a major threat in its virulence and lack of effective treatment. The currently lacking standards of care, as well as the lengthy drug approval process, demonstrate the pressing demand for treatment for infections. The present study screened 1586 clinically approved drugs in an attempt to identify repurposable compounds against , a relative strain that shares many physical and genetic characteristics with . Our study yielded five drugs that successfully inhibited growth: dichlorophen, oxiconazole, suloctidil, bithionol, and hexestrol. These drugs exhibited varying levels of efficacy in broad-spectrum experiments against several Gram-positive and Gram-negative bacterial strains, with hexestrol showing the greatest inhibition across all tested strains. Through tests for the efficacy of each drug on , bithionol was the single most potent compound on both solid and liquid media and exhibited even greater eradication of in combination with suloctidil on solid agar. This multifaceted study of approved drugs demonstrates the potential to repurpose these drugs as treatments for anthrax disease in a time-efficient manner to address a global health need.
在困扰人类的众多传染病中，由[具体病原体未给出]引起的炭疽病，因其毒性强且缺乏有效治疗方法而构成重大威胁。目前护理标准的缺失以及漫长的药物审批过程，表明对[具体病原体感染]治疗的迫切需求。本研究筛选了1586种临床批准的药物，试图确定可重新用于治疗[具体病原体名称未给出]的化合物，[具体病原体名称未给出]是一种与[另一种具体病原体名称未给出]具有许多物理和遗传特征的相关菌株。我们的研究产生了五种成功抑制[具体病原体名称未给出]生长的药物：双氯芬、奥昔康唑、舒洛地尔、硫双二氯酚和己烯雌酚。这些药物在针对几种革兰氏阳性和革兰氏阴性细菌菌株的广谱实验中表现出不同程度的疗效，己烯雌酚在所有测试菌株中显示出最大的抑制作用。通过对每种药物对[具体病原体名称未给出]的疗效测试，硫双二氯酚是在固体和液体培养基上最有效的单一化合物，并且在固体琼脂上与舒洛地尔联合使用时对[具体病原体名称未给出]的根除效果更佳。这项对批准药物的多方面研究表明，有可能及时将这些药物重新用作炭疽病的治疗方法，以满足全球健康需求。
