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本文引用的文献

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Binaural Pitch Fusion in Children With Normal Hearing, Hearing Aids, and Cochlear Implants.听力正常、佩戴助听器及接受人工耳蜗植入的儿童的双耳音调融合
Ear Hear. 2020 Nov/Dec;41(6):1545-1559. doi: 10.1097/AUD.0000000000000874.
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Effects of Electrode Location on Estimates of Neural Health in Humans with Cochlear Implants.电极位置对人工耳蜗植入者神经健康评估的影响。
J Assoc Res Otolaryngol. 2020 Jun;21(3):259-275. doi: 10.1007/s10162-020-00749-0. Epub 2020 Apr 27.
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Polarity Sensitivity as a Potential Correlate of Neural Degeneration in Cochlear Implant Users.极性敏感性作为人工耳蜗使用者神经退变的潜在关联因素
J Assoc Res Otolaryngol. 2020 Feb;21(1):89-104. doi: 10.1007/s10162-020-00742-7. Epub 2020 Feb 4.
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Effects of Early Acoustic Hearing on Speech Perception and Language for Pediatric Cochlear Implant Recipients.早期声觉对儿童人工耳蜗植入者言语感知和语言的影响。
J Speech Lang Hear Res. 2019 Sep 20;62(9):3620-3637. doi: 10.1044/2019_JSLHR-H-18-0255. Epub 2019 Sep 13.
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Pitch Matching Adapts Even for Bilateral Cochlear Implant Users with Relatively Small Initial Pitch Differences Across the Ears.双耳间初始音高差异较小的双侧人工耳蜗植入者也能适应音高匹配。
J Assoc Res Otolaryngol. 2019 Dec;20(6):595-603. doi: 10.1007/s10162-019-00733-3. Epub 2019 Aug 5.
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Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes.电转移神经生长因子基因增强以改善人工耳蜗植入的听力效果。
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AAV-Mediated Neurotrophin Gene Therapy Promotes Improved Survival of Cochlear Spiral Ganglion Neurons in Neonatally Deafened Cats: Comparison of AAV2-hBDNF and AAV5-hGDNF.AAV 介导的神经营养因子基因治疗促进新生聋猫耳蜗螺旋神经节神经元存活的改善：AAV2-hBDNF 和 AAV5-hGDNF 的比较。
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Animal and human studies on developmental monaural hearing loss.动物和人类对单侧性发育性听力损失的研究。
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A Site-Selection Strategy Based on Polarity Sensitivity for Cochlear Implants: Effects on Spectro-Temporal Resolution and Speech Perception.基于极性敏感性的人工耳蜗植入选址策略：对频谱-时间分辨率和语音感知的影响。
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Stem Cell Based Drug Delivery for Protection of Auditory Neurons in a Guinea Pig Model of Cochlear Implantation.基于干细胞的药物递送用于在豚鼠人工耳蜗植入模型中保护听觉神经元
Front Cell Neurosci. 2019 May 14;13:177. doi: 10.3389/fncel.2019.00177. eCollection 2019.

人工耳蜗及其他内耳假体：现状与未来。

Cochlear implants and other inner ear prostheses: today and tomorrow.

作者信息

Reiss Lina Aj

机构信息

Oregon Health & Science University, Otolaryngology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mailcode NRC04, OHSU, Portland 97239, United States.

出版信息

Curr Opin Physiol. 2020 Dec;18:49-55. doi: 10.1016/j.cophys.2020.08.001. Epub 2020 Aug 14.

DOI:10.1016/j.cophys.2020.08.001
PMID:32905432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7469954/
Abstract

Cochlear implants (CIs) are implantable auditory prostheses designed to restore access to sound in deaf individuals via direct electrical stimulation of the auditory nerve. While CIs have been successful in restoring speech perception to many deaf patients, outcomes are variable and speech recognition in noise remains a problem. This chapter will review the factors underlying this variability, and discuss significant recent innovations to address these issues including neural health preservation, characterization, and regeneration, and other inner ear prostheses. The emerging role of central auditory plasticity will also be discussed. Together, these advances will point to the likely future directions for advancing the next generation of CIs and other inner ear prostheses.

摘要

人工耳蜗（CIs）是一种可植入的听觉假体，旨在通过直接电刺激听神经来恢复聋人对声音的感知。虽然人工耳蜗已成功地为许多聋人患者恢复了言语感知，但结果存在差异，且噪声环境下的言语识别仍然是一个问题。本章将回顾造成这种差异的潜在因素，并讨论近期为解决这些问题所取得的重大创新，包括神经健康的保护、特征描述和再生，以及其他内耳假体。还将讨论中枢听觉可塑性的新作用。这些进展共同指出了推进下一代人工耳蜗和其他内耳假体的未来可能方向。