了解应激颗粒在恶性肿瘤患者化疗过程中的作用。
Understanding the roles of stress granule during chemotherapy for patients with malignant tumors.
作者信息
Zhan Yuting, Wang Haihua, Ning Yue, Zheng Hongmei, Liu Sile, Yang Yang, Zhou Ming, Fan Songqing
机构信息
Department of Pathology, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Cancer Research Institute Xiangya School of Medicine, Central South University Changsha 410078, Hunan, China.
出版信息
Am J Cancer Res. 2020 Aug 1;10(8):2226-2241. eCollection 2020.
Abstract
The assembly of stress granules (SGs) is a conserved mechanism to regulate protein synthesis under cell stress, where the translation of global protein is silenced and selective protein synthesis for survival maintains. SG formation confers survival advantages and chemotherapeutic resistance to malignant cells. Targeting SG assembly may represent a potential treatment strategy to overcome the primary and acquired chemotherapeutic resistance and enhance curative effect. We conduct a comprehensive review of the published literatures focusing on the drugs that potentially induce SGs and the related mechanism, retrospect the relationship between SGs and drug resistance related proteins, illuminate the regulated pathways and potential targets for SG assembly, and discuss future directions of overcoming the resistance to chemotherapy.
摘要
应激颗粒（SGs）的组装是一种在细胞应激状态下调节蛋白质合成的保守机制，在此过程中整体蛋白质翻译被沉默，而用于细胞存活的选择性蛋白质合成得以维持。SGs的形成赋予恶性细胞生存优势和化疗耐药性。靶向SGs组装可能是一种潜在的治疗策略，以克服原发性和获得性化疗耐药性并提高疗效。我们对已发表的文献进行了全面综述，重点关注潜在诱导SGs的药物及其相关机制，回顾SGs与耐药相关蛋白之间的关系，阐明SGs组装的调控途径和潜在靶点，并讨论克服化疗耐药性的未来方向。
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