Jurgensen Andrew, Qannus Abd Assalam, Gupta Aditi
Division of Nephrology, Kidney Institute and Center for Transplantation, Kansas City, KS.
Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS.
Curr Transplant Rep. 2020 Sep;7:145-153. doi: 10.1007/s40472-020-00284-0. Epub 2020 Jul 1.
Cognitive impairment is common in kidney transplant recipients and affects quality of life, graft survival, morbidity, and mortality. In this review article we discuss the epidemiology, diagnosis, pathophysiology and future directions for cognitive impairment in kidney transplantation. We describe the potential role of pre-transplant cognition, immunosuppression and peri-transplant factors in post -transplant cognitive impairment.
A majority of patients with kidney transplant have cognitive impairment. Cognitive impairment affects both pre-transplant evaluation and post-transplant outcomes. Failure to identify patients with cognitive impairment can withhold appropriate care and timely intervention.
Cognitive impairment is common in kidney transplant and affects outcomes. Studies addressing modifiable risk factors and possible interventions to slow cognitive decline in patients with kidney disease are needed.
认知障碍在肾移植受者中很常见，会影响生活质量、移植物存活、发病率和死亡率。在这篇综述文章中，我们讨论肾移植中认知障碍的流行病学、诊断、病理生理学及未来研究方向。我们描述了移植前认知、免疫抑制和移植围手术期因素在移植后认知障碍中的潜在作用。
大多数肾移植患者存在认知障碍。认知障碍会影响移植前评估和移植后结局。未能识别出认知障碍患者可能会导致无法提供适当的护理和及时的干预。
认知障碍在肾移植中很常见且会影响结局。需要开展研究以探讨可改变的风险因素以及可能延缓肾病患者认知功能衰退的干预措施。
