分枝杆菌与巨噬细胞凋亡：生存的复杂斗争
Mycobacteria and Macrophage Apoptosis: Complex Struggle for Survival.
作者信息
Bermudez Luiz E, Danelishvili Lia, Early Julie
机构信息
Department of Biomedical Sciences, College of Veterinary Medicine, and the Department of Microbiology, College of Science, Oregon State University, Corvallis.
Department of Biomedical Sciences, Oregon State University, Corvallis.
出版信息
Microbe Wash DC. 2006 Aug;1(8):372-375. doi: 10.1128/microbe.1.372.1.
Abstract
-infected macrophages undergo apoptosis, but suppresses apoptosis and triggers necrosis.
摘要
受感染的巨噬细胞会发生凋亡，但能抑制凋亡并引发坏死。
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本文引用的文献
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Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.结核分枝杆菌的强毒临床分离株生长迅速，可诱导小鼠巨噬细胞发生细胞坏死，但凋亡程度极小。
J Leukoc Biol. 2006 Jan;79(1):80-6. doi: 10.1189/jlb.0505250. Epub 2005 Nov 7.
2
Intracellular phenotype of Mycobacterium avium enters macrophages primarily by a macropinocytosis-like mechanism and survives in a compartment that differs from that with extracellular phenotype.鸟分枝杆菌的细胞内表型主要通过一种类似巨吞饮作用的机制进入巨噬细胞，并在一个与细胞外表型不同的区室中存活。
Cell Biol Int. 2004;28(5):411-9. doi: 10.1016/j.cellbi.2004.03.010.
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Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility.海分枝杆菌可从吞噬体中逃逸，并通过基于肌动蛋白的运动性进行推进。
J Exp Med. 2003 Nov 3;198(9):1361-8. doi: 10.1084/jem.20031072.
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Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells.结核分枝杆菌感染会导致人类巨噬细胞和肺泡上皮细胞出现不同程度的凋亡和坏死。
Cell Microbiol. 2003 Sep;5(9):649-60. doi: 10.1046/j.1462-5822.2003.00312.x.
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Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1.结核分枝杆菌在宿主巨噬细胞中的存活涉及对凋亡的抵抗，这种抵抗依赖于抗凋亡Bcl-2家族成员Mcl-1的诱导。
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