Starnes V A, Oyer P E, Portner P M, Ramasamy N, Miller P J, Stinson E B, Baldwin J C, Ream A K, Wyner J, Shumway N E
Department of Cardiovascular Surgery, Stanford University Medical Center 94305.
J Thorac Cardiovasc Surg. 1988 Jul;96(1):62-71.
The electrically driven Novacor implantable left ventricular assist device has been implanted in six patients (four men and two women) since Sept. 7, 1984. In four of the six patients (67%) the device was a successful bridge to cardiac transplantation. One patient died of multiple organ failure and Candida sepsis after 16 days of support with the device. One patient died in the operating room of uncontrollable hemorrhage and biventricular failure caused by severe cardiac rejection. Three patients are alive with cardiac transplants 38, 17, and 10 months after transplantation. One patient died after cardiac transplantation of presumed sepsis. The Novacor left ventricular assist device performed in all cases without mechanical or electrical failure. Excluding the intraoperative death, assist duration ranged from 2 to 16 days. The cardiac index (synonymous with device output) ranged from 2.4 to 3.4 L/min/m2. No embolic events (cerebrovascular or systemic) occurred during assistance with the device. Minimal red cell hemolysis was documented during the period of support. The Novacor left ventricular assist device is a safe and effective bridge to cardiac transplantation in patients with refractory cardiogenic shock.
自1984年9月7日以来，已将电动诺瓦科尔植入式左心室辅助装置植入6例患者（4例男性和2例女性）体内。在这6例患者中的4例（67%），该装置成功地成为心脏移植的桥梁。1例患者在使用该装置支持16天后死于多器官衰竭和念珠菌败血症。1例患者在手术室死于严重心脏排斥反应导致的无法控制的出血和双心室衰竭。3例患者在心脏移植后38、17和10个月存活。1例患者在心脏移植后死于疑似败血症。诺瓦科尔左心室辅助装置在所有病例中均未出现机械或电气故障。排除术中死亡病例，辅助时间为2至16天。心脏指数（与装置输出同义）为2.4至3.4 L/（min·m²）。在使用该装置辅助期间未发生栓塞事件（脑血管或全身性）。在支持期间记录到最小程度的红细胞溶血。诺瓦科尔左心室辅助装置是治疗难治性心源性休克患者心脏移植的安全有效桥梁。
