无周期性锐波复合波的克雅氏病：一项临床、脑电图及病理学研究

Creutzfeldt-Jakob disease without periodic sharp wave complexes: a clinical, electroencephalographic, and pathologic study.

作者信息

Zochodne D W, Young G B, McLachlan R S, Gilbert J J, Vinters H V, Kaufmann J C

机构信息

Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.

出版信息

Neurology. 1988 Jul;38(7):1056-60. doi: 10.1212/wnl.38.7.1056.

DOI:10.1212/wnl.38.7.1056

PMID:3290701

Abstract

A comparison of clinical, EEG, and pathologic features was carried out on all cases of autopsy-proven Creutzfeldt-Jakob disease (CJD) studied over the last 10 years. Periodic sharp wave complexes (PSWCs) were present in three but absent in seven patients. Myoclonus was documented in two of the three with and in only one of the seven without PSWCs. The three with PSWCs had severe neocortical and at least mild thalamic involvement; those without PSWCs had more variable disease topography. The diagnosis of CJD should not be rejected if PSWCs are absent.

摘要

对过去10年中所有经尸检证实的克雅氏病（CJD）病例进行了临床、脑电图和病理特征的比较。10例患者中，3例出现周期性锐波复合波（PSWCs），7例未出现。3例出现PSWCs的患者中有2例记录到肌阵挛，7例未出现PSWCs的患者中只有1例记录到肌阵挛。3例出现PSWCs的患者有严重的新皮质受累，至少丘脑轻度受累；未出现PSWCs的患者病变部位变化更大。如果未出现PSWCs，不应排除CJD的诊断。