Bornstein M B, Miller A, Slagle S, Weitzman M, Crystal H, Drexler E, Keilson M, Merriam A, Wassertheil-Smoller S, Spada V
Department of Neurology/Neurosciences, Albert Einstein College of Medicine, New York, NY 10461.
Neurology. 1988 Jul;38(7 Suppl 2):66-9.
COP-1 is one of a series of polypeptide preparations developed to stimulate myelin basic protein (MBP), a natural component of the myelin sheath. MBP in Freund's complete adjuvant induces experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). In saline, MBP suppresses EAE. This is the rationale for the use of COP-1 in MS.
共聚肽-1（COP-1）是为刺激髓鞘碱性蛋白（MBP，髓鞘的一种天然成分）而研发的一系列多肽制剂之一。弗氏完全佐剂中的MBP可诱发实验性自身免疫性脑脊髓炎（EAE），这是一种多发性硬化症（MS）的动物模型。在生理盐水中，MBP可抑制EAE。这就是在MS中使用COP-1的理论依据。
