Istituto Ortopedico "G. Pini", Milan, Italy.
Southland Hospital, Invercargill, New Zealand.
Hip Int. 2020 Sep;30(1_suppl):7-11. doi: 10.1177/1120700020917125.
Infections remains the most feared complication in total hip arthroplasty (THA). New strategies of PJI prevention includes coating of conventional implants. Defensive Antibacterial Coating (DAC), an antibacterial hydrogel coating made of hyaluronan, poly-D and L-lactide can protect biomaterials as an effective barrier at the time of implantation. In addition, it can be used with topical antibiotics to prevent early colonisation of the implant.
This manuscript describes the detailed function of the DAC in general as well as an analysis of its use in revision THA in a series of 28 patients in a short-term follow-up.Its use in patients undergoing cementless re-implantation after 2-staged procedures in THA is described in detail within the manuscript.
DAC found to be effective in terms of infection control and safety in our patient cohort and has been expanded for cementless 1-staged revisions in PJI of the hip in our institution.
感染仍然是全髋关节置换术(THA)最令人恐惧的并发症。预防 PJI 的新策略包括对传统植入物进行涂层处理。防御性抗菌涂层(DAC)是一种由透明质酸、聚 D 和 L-丙交酯制成的抗菌水凝胶涂层,可在植入时作为有效的屏障来保护生物材料。此外,它可以与局部抗生素一起使用,以防止植入物的早期定植。
本文描述了 DAC 的一般详细功能,以及在一组 28 名短期随访的翻修 THA 患者中的使用分析。本文详细描述了在 THA 的两期手术后进行非骨水泥再植入的患者中使用 DAC 的情况。
在我们的患者队列中,DAC 在控制感染和安全性方面被证明是有效的,并已在我们的机构中扩展用于髋关节 PJI 的非骨水泥一期翻修。