Bellucci S, Kedra W, Ajzenberg N, Tobelem G, Caen J
Départment d'Angiohématologie, Hôpital Lariboisière, Paris, France.
Nouv Rev Fr Hematol (1978). 1988;30(1-2):103-7.
Raynaud's phenomenon, either idiopathic or secondary is often severe. It is due to a vasospasm in response to cold, and an increase in sympathetic tone, hyperviscosity and sometimes hyperactivation of platelets and erythrocytes have been reported. New drugs have been developed such as ketanserin, which is a specific inhibitor of serotonin S2 receptors, and has led to a positive response in 38%-80% of patients. The prostaglandins PGE1 and PGI2 were given i.v. in refractory patients and led to a beneficial effect in 50%-70% of cases. These data seem to justify the development of prostaglandin analogues.
雷诺现象，无论是特发性还是继发性的，通常都很严重。它是由寒冷引起的血管痉挛所致，据报道，交感神经张力增加、血液高黏滞度，有时血小板和红细胞过度活化也与之相关。已研发出如酮色林等新药，它是5-羟色胺S2受体的特异性抑制剂，在38%-80%的患者中产生了阳性反应。对于难治性患者，静脉注射前列腺素PGE1和PGI2，50%-70%的病例有有益效果。这些数据似乎证明了前列腺素类似物研发的合理性。
