Belch J J, Newman P, Drury J K, Capell H, Leiberman P, James W B, Forbes C D, Prentice C R
Thromb Haemost. 1981 Jun 30;45(3):255-6.
There is evidence to suggest that platelet activation occurs in Raynaud's syndrome. We evaluated the effect of prostacyclin (PGI2) a potent antiplatelet and vasodilator agent in 5 female patients with Raynaud's syndrome. Outpatient visits were made at weekly intervals for 4 weeks. At the first visit buffer solution (Wellcome Laboratories) was infused intravenously for 5 hrs, thereafter three five hr infusions of PGI2 at a peak dose of 10 ng/Kg/min were given. Six weeks after the infusions patients were reviewed. Symptomatic improvement, including healing of ischaemic ulcers, occurred in 4 out of 5 patients. Thermography confirmed an increase in hand temperature after PCI2. Subjective and objective improvement has persisted for at least 6 weeks after the last treatment.
有证据表明血小板活化发生在雷诺综合征中。我们评估了前列环素（PGI2），一种强效抗血小板和血管扩张剂，对5名雷诺综合征女性患者的影响。门诊随访每周进行一次，共4周。第一次就诊时，静脉输注缓冲溶液（威康实验室）5小时，此后给予三次5小时的PGI2输注，峰值剂量为10 ng/Kg/分钟。输注后六周对患者进行复查。5名患者中有4名出现了症状改善，包括缺血性溃疡愈合。热成像证实PCI2后手部温度升高。主观和客观改善在最后一次治疗后至少持续了6周。
