Zhang Yuchao, Wu Wenbin, Liu Yanli, Guan Yichun, Wang Xingling, Jia Liting
Department of Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Neonatal Screening Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Int J Endocrinol. 2020 Aug 18;2020:1056484. doi: 10.1155/2020/1056484. eCollection 2020.
To investigate the association between high-normal preconception TSH levels and reproductive outcomes in infertile women undergoing the first single fresh D5 blastocyst transfer.
This was a retrospective study. Euthyroid patients undergoing the first single fresh D5 blastocyst transfer from January 2018 to May 2019 were initially included. The patients were divided into a low TSH (0.27-2.5 mIU/L) group and a high-normal TSH (2.5-4.2 mIU/L) group. The reproductive outcomes were compared between the groups.
A total of 824 women were ultimately included, 460 of whom had serum TSH levels less than 2.5 mIU/L and 364 of whom had serum TSH levels between 2.5 and 4.2 mIU/L. The patients were highly homogeneous in terms of general characteristics. High-normal TSH levels had no adverse impact on the clinical pregnancy rate, miscarriage rate, or live birth rate (respectively, aOR = 0.84, 0.65, 0.61, and =0.234, 0.145, 0.083). No significant differences were observed in terms of gestational age, single live birth rates, birth weight, or birth length.
High-normal TSH levels did not significantly influence reproductive outcomes in infertile women undergoing the first single fresh D5 blastocyst transfer. Further studies are needed to test whether the results might be applicable to a wider population.
探讨首次接受单枚新鲜D5囊胚移植的不孕女性孕前促甲状腺激素（TSH）水平处于高正常范围与生殖结局之间的关联。
这是一项回顾性研究。最初纳入2018年1月至2019年5月期间首次接受单枚新鲜D5囊胚移植的甲状腺功能正常的患者。将患者分为低TSH（0.27 - 2.5 mIU/L）组和高正常TSH（2.5 - 4.2 mIU/L）组。比较两组的生殖结局。
最终共纳入824名女性，其中460名血清TSH水平低于2.5 mIU/L，364名血清TSH水平在2.5至4.2 mIU/L之间。患者在一般特征方面高度同质。高正常TSH水平对临床妊娠率、流产率或活产率没有不利影响（分别为调整后比值比 = 0.84、0.65、0.61，P值分别为0.234、0.145、0.083）。在孕周、单胎活产率、出生体重或出生身长方面未观察到显著差异。
对于首次接受单枚新鲜D5囊胚移植的不孕女性，高正常TSH水平对生殖结局无显著影响。需要进一步研究以检验这些结果是否适用于更广泛的人群。
