Department of Reproductive Medicine, The Third Affiliated Hospital of Zhengzhou University, No. 7 Kangfuqian Street, Erqi, Zhengzhou, 45005, Henan, China.
Neonatal Screening Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Reprod Health. 2022 Jun 22;19(1):145. doi: 10.1186/s12978-022-01455-1.
The present study investigated the role of β-hCG in predicting reproductive outcomes and established optimal β-hCG cutoff values in women undergoing cleavage embryo transfer.
The patients were transferred with fresh or frozen-thawed embryos and had serum β-hCG levels tested on the 14th day post-embryo transfer. Serum β-hCG levels were compared between different groups. Different cutoff values of β-hCG were established and used to divide the patients into different groups. Reproductive outcomes between groups based on β-hCG levels were compared.
Significant discrepancies in general characteristics were observed in the subgroups. The cutoff values of β-hCG for predicting the presence/absence of pregnancy, biochemical pregnancy/clinical pregnancy, presence/absence of adverse pregnancy outcomes, and singleton/twin live birth in the cleavage groups were 89.6, 241.1, 585.9, and 981.1 mIU/L, respectively. Biochemical pregnancy rates and adverse pregnancy outcome rates significantly decreased from the low β-hCG group to the higher β-hCG group in sequence. Significantly higher full-term live birth rates were observed in the highest β-hCG group (P < 0.001).
Serum β-hCG levels were strongly associated with reproductive outcomes. However, the interpretation of β-hCG levels must consider the number and quality of embryos and transfer protocols. When β-hCG was tested on a fixed day post-ET, different cutoff values were required for the prediction of early clinical outcomes. The association between β-hCG and obstetric outcomes must be investigated.
本研究旨在探讨β-hCG 在预测妊娠结局中的作用，并确定行卵裂期胚胎移植妇女的最佳β-hCG 截断值。
患者行新鲜或冻融胚胎移植，于胚胎移植后第 14 天检测血清β-hCG 水平。比较不同组间血清β-hCG 水平。建立不同的β-hCG 截断值，将患者分为不同组。比较不同β-hCG 水平组间的妊娠结局。
亚组间一般特征存在显著差异。预测妊娠、生化妊娠/临床妊娠、不良妊娠结局、单胎/双胎活产的β-hCG 截断值分别为 89.6、241.1、585.9 和 981.1 mIU/L。生化妊娠率和不良妊娠结局率从低β-hCG 组到高β-hCG 组依次显著降低。最高β-hCG 组足月活产率显著升高（P < 0.001）。
血清β-hCG 水平与妊娠结局密切相关。然而，β-hCG 水平的解读必须考虑胚胎的数量和质量以及移植方案。当在固定的 ET 后日检测β-hCG 时，预测早期临床结局需要不同的截断值。必须研究β-hCG 与产科结局的关系。
