Escobar-Sevilla Joaquín, Bustos Merlo Antonio, Garcia Martínez Carmen, Mediavilla Garcia Juan Diego
Hospital Universitario Virgen de las Nieves, Granada, Spain.
Eur J Case Rep Intern Med. 2020 Jun 25;7(9):001596. doi: 10.12890/2020_001596. eCollection 2020.
Reactivation of human parvovirus B19 is exceptional and characteristic of immunosuppression, with anaemia being the predominant manifestation although pancytopenia and thrombotic microangiopathy may also occur. We describe a patient with a history of diffuse large B-cell lymphoma with pure erythrocyte aplasia due to reactivation of parvovirus B19, who was treated with corticosteroids and immunoglobulins.
Infection with human parvovirus B19 is identified by polymerase chain reaction (PCR) testing of blood and the presence of typical giant proerythroblasts in the bone marrow.Cytomegalovirus infection should be considered in immunosuppressed patients with fever and non-specific symptoms with haematological changes.The treatment of persistent infection in immunosuppressed patients is based on the administration of IV immunoglobulins at high doses.
人类细小病毒B19再激活情况罕见，是免疫抑制的特征表现，贫血是主要表现，不过全血细胞减少和血栓性微血管病也可能发生。我们描述了一名有弥漫性大B细胞淋巴瘤病史的患者，因细小病毒B19再激活导致纯红细胞再生障碍性贫血，接受了皮质类固醇和免疫球蛋白治疗。
通过血液聚合酶链反应（PCR）检测及骨髓中典型巨大早幼红细胞的存在来确定人类细小病毒B19感染。对于有发热及血液学改变的非特异性症状的免疫抑制患者，应考虑巨细胞病毒感染。免疫抑制患者持续性感染的治疗基于大剂量静脉注射免疫球蛋白。
