Schröder Christoph, Roeles Johannes, Schwarzer Adrian, Heuser Michael, Retzlaff Jennifer, Hiß Marcus
Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland.
Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation, Medizinische Hochschule Hannover, Hannover, Deutschland.
Internist (Berl). 2021 Jul;62(7):768-771. doi: 10.1007/s00108-021-00955-9. Epub 2021 Feb 12.
This article presents a case of pure red cell aplasia in a 35-year-old heart transplant recipient on chronic hemodialysis. Elevated parvovirus B19 immunoglobulin M blood levels were detected along with a high viral load of 80 billion IU/ml quantified by polymerase chain reaction. Bone marrow examination revealed giant proerythroblasts confirming parvovirus B19 infection. High-dose intravenous immunoglobulin was used for treatment. Anaemia had significantly improved 4 weeks later. Parvovirus B19 infection should be excluded in organ transplant recipients with anaemia due to ineffective erythropoiesis.
本文介绍了一名35岁接受慢性血液透析的心脏移植受者发生纯红细胞再生障碍性贫血的病例。检测到细小病毒B19免疫球蛋白M血液水平升高，同时通过聚合酶链反应定量检测到病毒载量高达800亿IU/ml。骨髓检查发现巨大早幼红细胞，证实存在细小病毒B19感染。采用大剂量静脉注射免疫球蛋白进行治疗。4周后贫血明显改善。对于因红细胞生成无效而贫血的器官移植受者，应排除细小病毒B19感染。
