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本文引用的文献

1
Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis.多种药物联合使用及超量多种药物联合使用与衰弱状态的关联：一项系统评价和荟萃分析
Eur Geriatr Med. 2019 Feb;10(1):9-36. doi: 10.1007/s41999-018-0124-5. Epub 2018 Nov 7.
2
Treatment of hypercholesterolaemia in older adults calls for a patient-centred approach.老年高胆固醇血症的治疗需要采取以患者为中心的方法。
Heart. 2020 Feb;106(4):261-266. doi: 10.1136/heartjnl-2019-315600. Epub 2019 Nov 28.
3
Decreasing incidence of upper age restriction enrollment criteria among cancer clinical trials.癌症临床试验中年龄上限标准的纳入标准降低。
J Geriatr Oncol. 2020 Apr;11(3):451-454. doi: 10.1016/j.jgo.2019.11.001. Epub 2019 Nov 8.
4
Prescribing medicines to older people-How to consider the impact of ageing on human organ and body functions.给老年人开药——如何考虑衰老对人体器官和身体功能的影响。
Br J Clin Pharmacol. 2020 Oct;86(10):1921-1930. doi: 10.1111/bcp.14094. Epub 2019 Dec 16.
5
Adequacy of Inclusion of Older Adults in NIH-Funded Phase III Clinical Trials.纳入老年人参与 NIH 资助的 III 期临床试验的充分性。
J Am Geriatr Soc. 2019 Feb;67(2):218-222. doi: 10.1111/jgs.15786. Epub 2019 Jan 29.
6
Under-representation of elderly in clinical trials: An analysis of the initial approval documents in the Food and Drug Administration database.临床试验中老年人代表性不足：对食品和药物管理局数据库中初始批准文件的分析。
Br J Clin Pharmacol. 2019 Apr;85(4):838-844. doi: 10.1111/bcp.13876. Epub 2019 Feb 23.
7
Exclusion of Elderly People from Randomized Clinical Trials of Drugs for Ischemic Heart Disease.老年人群被排除在缺血性心脏病药物随机临床试验之外。
J Am Geriatr Soc. 2017 Nov;65(11):2354-2361. doi: 10.1111/jgs.14833. Epub 2017 Mar 17.
8
Adverse drug reactions in special populations - the elderly.特殊人群中的药物不良反应——老年人
Br J Clin Pharmacol. 2015 Oct;80(4):796-807. doi: 10.1111/bcp.12596. Epub 2015 May 22.
9
Participation of older people in preauthorization trials of recently approved medicines.老年人参与近期获批药物的预授权试验。
J Am Geriatr Soc. 2014 Oct;62(10):1883-90. doi: 10.1111/jgs.13067. Epub 2014 Oct 3.
10
Exclusion of older adults from ongoing clinical trials about type 2 diabetes mellitus.将老年人排除在正在进行的 2 型糖尿病临床试验之外。
J Am Geriatr Soc. 2013 May;61(5):734-8. doi: 10.1111/jgs.12215. Epub 2013 Apr 16.

Underrepresentation of the elderly in clinical trials, time for action.

作者信息

van Marum Rob J

机构信息

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.

Departments of Clinical Pharmacology and Geriatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.

出版信息

Br J Clin Pharmacol. 2020 Oct;86(10):2014-2016. doi: 10.1111/bcp.14539. Epub 2020 Sep 9.

DOI:10.1111/bcp.14539
PMID:32909294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7495271/
Abstract
摘要