COVID-19 相关的脑脊髓神经根炎和抗水通道蛋白 4 抗体阳性：病因还是巧合？
COVID-19 associated with encephalomyeloradiculitis and positive anti-aquaporin-4 antibodies: Cause or coincidence?
机构信息
Department of Radiology, Clínica de Diagnóstico por Imagem (CDPI)/DASA, Rio de Janeiro, Brazil/Department of Radiology, Hospital Universitário Antônio Pedro, Federal Fluminense University, Niterói, Brazil.
Department of Neurology, Hospital Universitário Pedro Ernesto, Rio de Janeiro, Brazil.
出版信息
Mult Scler. 2021 May;27(6):973-976. doi: 10.1177/1352458520949988. Epub 2020 Sep 10.
Neurologic complications are being recognized as important outcomes of coronavirus disease 2019 (COVID-19). Pathogenesis is varied and incompletely understood, and may include neuroinvasion, indirect post-infectious neuroinflammation, and cerebrovascular pathologies. We present a case of COVID-19-related encephalomyeloradiculitis with clinical and magnetic resonance imaging characteristics of neuromyelitis optica spectrum disorders that was associated with anti-aquaporin-4 antibodies. Our case suggests post-infectious autoimmunity as a mechanism in at least a subset of patients with COVID-19-related neurologic disease.
神经并发症正被认为是 2019 冠状病毒病（COVID-19）的重要结果。其发病机制多种多样且尚未完全了解，可能包括神经入侵、间接感染后神经炎症和脑血管疾病。我们报告了一例 COVID-19 相关的脑脊髓神经根炎，其临床和磁共振成像特征符合视神经脊髓炎谱系障碍，与抗水通道蛋白-4 抗体有关。我们的病例提示感染后自身免疫可能是 COVID-19 相关神经疾病患者中至少一部分患者的发病机制。
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