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视神经脊髓炎谱系疾病(NMOSD)表现为急性横贯性脊髓炎,伴水通道蛋白 4 抗体阳性。

Neuromyelitis optica spectrum disorder (NMOSD) presenting as acute transverse myelitis with positive aquaporin 4 antibodies.

机构信息

General Medicine, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK

Stroke and Neurology, James Paget University Hospital NHS Foundation Trust, Great Yarmouth, UK.

出版信息

BMJ Case Rep. 2021 Jan 27;14(1):e238992. doi: 10.1136/bcr-2020-238992.

DOI:10.1136/bcr-2020-238992
PMID:33504530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7843326/
Abstract

An 80-year-old, previously healthy patient presents with acute transverse myelitis with sensory level at T8. The MRI scan of the spinal cord showed longitudinal extensive transverse myelitis, and she tested positive for aquaporin 4 antibodies in serum. She received treatment with intravenous and oral steroids, with no improvement and then underwent plasma exchange. She was then started on azathioprine for prevention of relapses, while continuing physiotherapy and occupational therapy. Eventually, she was transferred to a specialised spinal cord centre for long-term rehabilitation.

摘要

一位 80 岁、既往健康的患者因急性横贯性脊髓炎出现 T8 感觉平面。脊髓 MRI 显示长节段横贯性脊髓炎,血清中 aquaporin 4 抗体阳性。她接受了静脉和口服类固醇治疗,但无改善,随后进行了血浆置换。随后开始使用硫唑嘌呤预防复发,同时继续进行物理治疗和职业治疗。最终,她被转至专门的脊髓中心进行长期康复治疗。

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Neuromyelitis optica spectrum disorder (NMOSD) presenting as acute transverse myelitis with positive aquaporin 4 antibodies.视神经脊髓炎谱系疾病(NMOSD)表现为急性横贯性脊髓炎,伴水通道蛋白 4 抗体阳性。
BMJ Case Rep. 2021 Jan 27;14(1):e238992. doi: 10.1136/bcr-2020-238992.
2
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本文引用的文献

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Experience with tocilizumab in patients with neuromyelitis optica spectrum disorders.托珠单抗治疗视神经脊髓炎谱系障碍患者的经验。
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Diagnosis and Treatment of NMO Spectrum Disorder and MOG-Encephalomyelitis.视神经脊髓炎谱系障碍和髓鞘少突胶质细胞糖蛋白脑病的诊断与治疗
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Neuromyelitis Optica: Deciphering a Complex Immune-Mediated Astrocytopathy.视神经脊髓炎:解读一种复杂的免疫介导性星形细胞病
J Neuroophthalmol. 2017 Sep;37(3):291-299. doi: 10.1097/WNO.0000000000000508.
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Multiple sclerosis, a treatable disease.多发性硬化症,一种可治疗的疾病。
Clin Med (Lond). 2016 Dec;16(Suppl 6):s53-s59. doi: 10.7861/clinmedicine.16-6-s53.