Department of Science, Tchaikapharma High Quality Medicines, Dimitrov Blvd.
Department of Informatics, New Bulgarian University, 21 Montevideo St, Sofia.
Blood Press Monit. 2021 Apr 1;26(2):160-168. doi: 10.1097/MBP.0000000000000486.
Hypertension is a chronic condition leading to increased stress on the heart and blood vessels, a critical risk factor for clinically significant events such as myocardial infarction heart failure, stroke and death. Chlorthalidone and hydrochlorothiazide are first-line antihypertensive agents for most patients with hypertension. The aim of our meta-analysis was to compare the efficacy and safety of both therapies in patients with hypertension. Searches of electronic databases PubMed, MEDLINE, Scopus, PsycInfo and eLIBRARY.ru, were performed. We used network meta-analysis to combine direct and indirect evidence. Forest plots and closed loops depict estimated results from studies included in our meta-analysis. Of 1289 identified sources, only 37 were included in our meta-analysis. Our analysis has demonstrated a slight superiority for chlorthalidone regarding SBP and not statistically significant differences regarding DBP. Simultaneously, hydrochlorothiazide seems to be a safer choice of therapy, as evidenced by the levels of serum potassium. The two diuretics can be used interchangeably.
高血压是一种慢性疾病，会导致心脏和血管承受更大的压力，是心肌梗死、心力衰竭、中风和死亡等临床重大事件的关键危险因素。氯噻酮和氢氯噻嗪是大多数高血压患者的一线降压药物。我们的荟萃分析旨在比较这两种治疗方法在高血压患者中的疗效和安全性。我们对电子数据库 PubMed、MEDLINE、Scopus、PsycInfo 和 eLIBRARY.ru 进行了检索。我们使用网络荟萃分析来结合直接和间接证据。森林图和闭合环描绘了我们荟萃分析中包含的研究的估计结果。在确定的 1289 个来源中，只有 37 个被纳入我们的荟萃分析。我们的分析表明，氯噻酮在收缩压方面略占优势，但在舒张压方面没有统计学上的显著差异。同时，氢氯噻嗪似乎是一种更安全的治疗选择，这可以从血清钾水平上得到证明。这两种利尿剂可以互换使用。
