From the Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Departments of Dermatology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York.
Dermatitis. 2021;32(4):214-219. doi: 10.1097/DER.0000000000000644.
Little is known about the impact of multimorbidity in childhood atopic dermatitis (AD).
We sought to determine the likelihood and predictors of chronic disease multimorbidity in childhood AD.
Data were examined for children (<18 years) in the 1996-2015 Medical Expenditure Panel Survey, an annual, representative sample of United States households. Multimorbidity was assessed using Charlson Comorbidity Index (CCI), Healthcare Utilization Project Chronic Comorbidity Indicator (HCUP-CCI) and frequency of atopic comorbidities.
Young children with mild-moderate and severe AD, and adolescents with mild-moderate AD had higher CCI scores. Similarly, young children and adolescents with mild-moderate and severe AD had increased HCUP-CCI scores. Children with AD and atopic disease had higher CCI and HCUP-CCI scores than children with either alone. Young children and adolescents with mild-moderate and severe AD had more atopic comorbidities.
Pediatric AD is associated with increased atopic and non-atopic multimorbidity. Comorbid atopic disease may identify a subset of children with AD who particularly benefit from enhanced screening and management of multimorbidity.
儿童特应性皮炎（AD）合并多种疾病的影响知之甚少。
我们旨在确定儿童 AD 中慢性疾病合并症的可能性和预测因素。
研究数据来自于 1996-2015 年美国医疗支出调查（MEPS），这是一项针对美国家庭的年度代表性样本。使用 Charlson 合并症指数（CCI）、医疗保健利用项目慢性合并症指标（HCUP-CCI）和特应性合并症的频率来评估合并症。
轻度至中度和重度 AD 的幼儿，以及轻度至中度 AD 的青少年的 CCI 评分较高。同样，轻度至中度和重度 AD 的幼儿和青少年的 HCUP-CCI 评分也较高。患有 AD 和特应性疾病的儿童的 CCI 和 HCUP-CCI 评分均高于仅患有其中一种疾病的儿童。轻度至中度和重度 AD 的幼儿和青少年有更多的特应性合并症。
儿科 AD 与特应性和非特应性合并症的增加有关。合并特应性疾病可能会确定一组 AD 儿童，他们特别需要增强对合并症的筛查和管理。
