Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, China; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Science, State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong, China.
The First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Yunnan Institute of Digestive Diseases, Kunming, China.
Cell Host Microbe. 2020 Nov 11;28(5):741-751.e4. doi: 10.1016/j.chom.2020.08.005. Epub 2020 Sep 9.
The human-gut-DNA virome is highly diverse and individual specific, but little is known of its variation at a population level. Here, we report the fecal DNA virome of 930 healthy adult subjects from two regions in China (Hong Kong and Yunnan) spanning six ethnicities (Han, Zang, Miao, Bai, Dai, and Hani), and including urban and rural residents for each ethnicity. Twenty host factors were found to significantly correlate with the human-gut virome variation, with geography carrying the strongest impact and ethnicity-distinct diets associating with certain viral species. Urbanization enhances interindividual dissimilarities between gut viromes, with the duration of urban residence associating with multiple bacteriophages, including Lactobacillus phage and Lactococcus phage. Overall, the gut virome presents more heterogeneity relative to the bacterial microbiome across the examined Chinese populations. This study highlights population-based variations and the importance of host and environmental factors in shaping the DNA virome in the human gut.
人类肠道 DNA 病毒组具有高度多样性和个体特异性，但对其在人群水平上的变异知之甚少。在这里，我们报告了来自中国两个地区（香港和云南）的 930 名健康成年受试者的粪便 DNA 病毒组，涵盖了六个民族（汉族、藏族、苗族、白族、傣族和哈尼族），包括每个民族的城市和农村居民。发现 20 个宿主因素与人类肠道病毒组的变异显著相关，其中地理因素的影响最强，而民族特有的饮食与某些病毒物种有关。城市化增强了肠道病毒组之间个体间的差异，城市居住时间与多种噬菌体有关，包括乳杆菌噬菌体和乳球菌噬菌体。总的来说，与所研究的中国人群的细菌微生物组相比，肠道病毒组呈现出更多的异质性。本研究强调了基于人群的变异以及宿主和环境因素在塑造人类肠道 DNA 病毒组方面的重要性。
