RNA mA修饰与非编码RNA之间的相互作用促进癌症生长和进展。
Crosstalk between RNA mA Modification and Non-coding RNA Contributes to Cancer Growth and Progression.
作者信息
Dai Fengsheng, Wu Yongyan, Lu Yan, An Changming, Zheng Xiwang, Dai Li, Guo Yujia, Zhang Linshi, Li Huizheng, Xu Wei, Gao Wei
机构信息
Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China; Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China.
Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China; Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China; Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, P. R. China.
出版信息
Mol Ther Nucleic Acids. 2020 Aug 8;22:62-71. doi: 10.1016/j.omtn.2020.08.004.
N6-methyladenosine (mA) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of mA regulators can lead to an imbalance in mA levels in cancer cells, leading to the dysregulated expression of oncogenes and tumor suppressor genes that may contribute to cancer development, patient response to chemoradiotherapy, and clinical prognosis. Recent studies demonstrate that non-coding RNAs are involved in epigenetic modification of both DNA and RNA in tumor cells, and may also affect the development and progression of cancer by targeting mA regulators. In this review, we describe the functional crosstalk between mA and non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, and illustrate their roles in tumor regulation. Finally, we discuss the significance of non-coding RNA and mA modification in the diagnosis, treatment, and prognosis of cancer patients, as well as potential future research directions.
N6-甲基腺苷（m6A）是最常见的RNA修饰，在正常发育和肿瘤发生中起重要作用。m6A调节剂的异常表达可导致癌细胞中m6A水平失衡，导致癌基因和肿瘤抑制基因的表达失调，这可能有助于癌症发展、患者对放化疗的反应以及临床预后。最近的研究表明，非编码RNA参与肿瘤细胞中DNA和RNA的表观遗传修饰，也可能通过靶向m6A调节剂影响癌症的发生和发展。在这篇综述中，我们描述了m6A与非编码RNA之间的功能相互作用，特别是微小RNA、长链非编码RNA和环状RNA，并阐述了它们在肿瘤调控中的作用。最后，我们讨论了非编码RNA和m6A修饰在癌症患者诊断、治疗和预后中的意义，以及未来潜在的研究方向。
Zotero 插件