生产和纯化钛-45的优化方法。
Optimized methods for production and purification of Titanium-45.
作者信息
Chaple Ivis F, Thiele Kathryn, Thaggard Grace, Fernandez Solana, Boros Eszter, Lapi Suzanne E
机构信息
Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794, USA.
出版信息
Appl Radiat Isot. 2020 Dec;166:109398. doi: 10.1016/j.apradiso.2020.109398. Epub 2020 Aug 29.
Titanium-45 (t = 3.08 h) is a radiometal with excellent nuclear characteristics, including a high positron branching ratio (85%) and low average positron energy (0.439 MeV), for the development of PET imaging agents. Ti was produced via the Sc(p,n)Ti reaction on the University of Alabama at Birmingham TR24 cyclotron in GBq quantities. Optimized separation methods were developed and preliminary radiochemistry studies were also carried out. This work shows Ti is a promising radiometal for future studies.
钛-45（半衰期t = 3.08小时）是一种具有优异核特性的放射性金属，包括高正电子分支比（85%）和低平均正电子能量（0.439兆电子伏特），适用于正电子发射断层显像（PET）成像剂的开发。钛是在阿拉巴马大学伯明翰分校的TR24回旋加速器上通过钪（Sc）（p，n）钛反应以吉贝可（GBq）量级生产的。开发了优化的分离方法，并进行了初步的放射化学研究。这项工作表明，钛是未来研究中一种有前景的放射性金属。
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