钛-45（Ti）放射化学及其在分子成像中的应用。

Saini Shefali, Lapi Suzanne E

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Pharmaceuticals (Basel). 2024 Apr 9;17(4):479. doi: 10.3390/ph17040479.

Molecular imaging is an important part of modern medicine which enables the non-invasive identification and characterization of diseases. With the advancement of radiochemistry and scanner technology, nuclear medicine is providing insight into efficient treatment options for individual patients. Titanium-45 (Ti) is a lesser-explored radionuclide that is garnering increasing interest for the development of positron emission tomography (PET) radiopharmaceuticals. This review discusses aspects of this radionuclide including production, purification, radiochemistry development, and molecular imaging studies.

分子影像学是现代医学的重要组成部分，它能够对疾病进行非侵入性识别和特征描述。随着放射化学和扫描仪技术的进步，核医学正在为个体患者的有效治疗方案提供深入见解。钛-45（Ti）是一种研究较少的放射性核素，正电子发射断层扫描（PET）放射性药物的开发对其兴趣日益增加。本文综述了该放射性核素的相关方面，包括生产、纯化、放射化学发展和分子影像学研究。