Division of Plastic Surgery, Department of Surgery, Faculty of Medicine, 26684Khon Kaen University, Khon Kaen, Thailand.
Department of Pediatrics, Faculty of Medicine, 26684Khon Kaen University, Khon Kaen, Thailand.
Cleft Palate Craniofac J. 2021 May;58(5):557-566. doi: 10.1177/1055665620956896. Epub 2020 Sep 10.
The objectives of this study were to obtain the birth prevalence of cleft lips and/or cleft palates (CL±P) and to identify potential associated risk factors in the population of the Northeast (NE) region of Thailand.
The data were collected from October 1, 2012, to September 30, 2013, for infant deliveries with nonsyndromic CL±P in all hospitals of 4 provinces in the region. Workshops were conducted to establish diagnostic criteria, treatment guidelines, referral systems, data collection, and data reporting. All patients included in this study, including a case (the child born with cleft lip and palate [CLP]) and 2 control cases (2 following children born without CLP in the same hospital), completed a questionnaire regarding demographics, cleft characteristics, and factors of interest such as alcohol intake, smoking, vitamin use, and medication. Unadjusted and adjusted odds ratio were presented for the magnitude of associations between proposed risk factors and CL±P along with 95% CIs.
The overall birth prevalence of CL±P was 1.93 per 1000 live births. There was a significant difference in percentages of infants with low birth weights ( = .03), family history of CL±P ( = .01) in cases than controls. Mothers who took self-medication or a menstrual regulation supplement were more likely to have the child with CL±P ( = .01 adjusted).
The prevalence of CL±P in the NE Thailand was high. Low infant birth weight, family history of CL±P, and the use of self-medication or menstrual regulation herbal supplement was significant factors.
本研究的目的是获得泰国东北部（NE）地区唇腭裂（CL±P）的出生流行率，并确定该人群中潜在的相关危险因素。
该数据收集于 2012 年 10 月 1 日至 2013 年 9 月 30 日，包括该地区 4 个省所有医院的非综合征性 CL±P 分娩婴儿。举办了研讨会以建立诊断标准、治疗指南、转诊系统、数据收集和数据报告。所有纳入本研究的患者，包括病例（出生时患有唇腭裂 [CLP] 的儿童）和 2 个对照病例（同一医院出生的无 CLP 的 2 个后续儿童），均完成了一份关于人口统计学、CL 特征以及感兴趣因素（如酒精摄入、吸烟、维生素使用和药物使用）的问卷。呈现了未经调整和调整后的优势比，以评估所提出的危险因素与 CL±P 之间的关联程度，并附有 95%置信区间。
CL±P 的总出生流行率为 1.93/1000 活产儿。病例组的低出生体重百分比（ =.03）和唇腭裂家族史（ =.01）与对照组存在显著差异。服用自我用药或月经调节补充剂的母亲更有可能生育患有 CL±P 的婴儿（调整后 =.01）。
泰国东北部 CL±P 的流行率较高。低婴儿出生体重、唇腭裂家族史以及自我用药或月经调节草药补充剂的使用是显著因素。
