Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD. (L.R.S., R.F.).
Department of Neurology, Children's National Hospital, Washington, DC. (D.H., C.C.P., J.L.C.).
Stroke. 2020 Oct;51(10):3174-3181. doi: 10.1161/STROKEAHA.120.029698. Epub 2020 Sep 11.
The use of mechanical thrombectomy for the treatment of acute childhood arterial ischemic stroke with large vessel occlusion is increasing, with mounting evidence for its feasibility and safety. Despite this emerging evidence, clear guidelines for patient selection, thrombectomy technique, and postprocedure care do not exist for the pediatric population. Due to unique features of stroke in children, neurologists and interventionalists must consider differences in patient size, anatomy, collateral vessels, imaging parameters, and expected outcomes that may impact appropriate patient selection and timing criteria. In addition, different causes of stroke and comorbidities in children must be considered and may alter the safety and efficacy of thrombectomy. To optimize the success of endovascular intervention in children, a multidisciplinary team should take into account these nuanced considerations when determining patient eligibility, developing a procedural approach, and formulating a postprocedure neurological monitoring and therapeutic plan.
机械取栓术用于治疗伴有大血管闭塞的儿童急性动脉缺血性脑卒中的应用正在增加,其可行性和安全性的证据也在不断增加。尽管有了这些新出现的证据,但对于儿科人群,尚无明确的患者选择、取栓技术和术后护理的指南。由于儿童中风的独特特征,神经科医生和介入医生必须考虑患者体型、解剖结构、侧支循环、影像学参数和预期结果的差异,这些差异可能会影响合适的患者选择和时间标准。此外,儿童中风的不同病因和合并症也必须考虑在内,并且可能会改变取栓术的安全性和有效性。为了优化儿童血管内介入治疗的成功率,多学科团队在确定患者的资格、制定手术方法以及制定术后神经监测和治疗计划时,都应考虑到这些细微的差异。