Wei Wen-Jun, Chen Xiao-Hui, Guo Tao, Liu Xiao-Qian, Zhao Yi, Wang Li-Li, Lan Jin-Xu, Li Han-Wei, Si Yan-Po, Wang Zhi-Min
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Mini Rev Med Chem. 2021;21(3):336-361. doi: 10.2174/1389557520666200910091905.
Many plants in the genus Zanthoxylum, belonging to the Rutaceae family, are used as folk medicines for the treatment of various diseases, which have gained much attention for their phytochemical and pharmacological activity investigations. Alkaloids are the largest secondary metabolites with structurally diverse types found in this genus and they demonstrate a wide range of biological activities. The aim of this review is to provide a summary on the isolation, classification, and biological properties of alkaloids from Zanthoxylum species, which also will bring more attention to other researchers for further biological study on alkaloids for the new drug development.
芸香科花椒属的许多植物被用作民间药物来治疗各种疾病，因其植物化学和药理活性研究而备受关注。生物碱是该属中发现的结构类型多样的最大一类次生代谢产物，它们具有广泛的生物活性。本综述的目的是总结花椒属植物生物碱的分离、分类和生物学特性，这也将引起其他研究人员对生物碱进行进一步生物学研究以开发新药的更多关注。
