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L中的生物碱:其植物化学、药理学及毒理学综述

Alkaloids in L: a review of its phytochemistry, pharmacology and toxicology.

作者信息

Li Xin-Lan, Sun Yan-Ping, Wang Meng, Wang Zhi-Bin, Kuang Hai-Xue

机构信息

Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China.

出版信息

Front Pharmacol. 2024 Aug 22;15:1440979. doi: 10.3389/fphar.2024.1440979. eCollection 2024.

Abstract

L. (, commonly known as "Bai Qu Cai" in China, belongs to the genus of the Papaveraceae family. It has rich medicinal value, such as alleviating coughs, asthma, spasms and pain. Recent studies have demonstrated that is abundant in various alkaloids, which are the primary components of and have a range of pharmacological effects, including anti-microbial, anti-inflammatory, anti-viral, and anti-tumor effects. So far, 94 alkaloids have been isolated from , including benzophenanthridine, protoberberine, aporphine, protopine and other types of alkaloids. This paper aims to review the research progress in phytochemistry, pharmacology and toxicology of alkaloids, in order to provide a theoretical basis for the application of in the field of medicinal chemistry and to afford reference for further research and development efforts.

摘要

L.(在中国通常被称为“白屈菜”)属于罂粟科的 属。它具有丰富的药用价值,如缓解咳嗽、哮喘、痉挛和疼痛。最近的研究表明, 富含多种生物碱,这些生物碱是 的主要成分,具有一系列药理作用,包括抗菌、抗炎、抗病毒和抗肿瘤作用。到目前为止,已从 中分离出94种生物碱,包括苯并菲啶、原小檗碱、阿朴啡、普罗托品等类型的生物碱。本文旨在综述 生物碱的植物化学、药理学和毒理学研究进展,为 在药物化学领域的应用提供理论依据,并为进一步的研发工作提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d927/11374730/a2c11522a59c/fphar-15-1440979-g001.jpg

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