Department of Neurosurgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.
Department of Neurosurgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.
J Stroke Cerebrovasc Dis. 2020 Oct;29(10):105069. doi: 10.1016/j.jstrokecerebrovasdis.2020.105069. Epub 2020 Jul 18.
Hemorrhagic stroke associated with essential thrombocythemia (ET) is very infrequent. Herein, we report a case of a 33-year-old woman with a 2-year history of ET who developed intracerebral and subarachnoid hemorrhage. Angiography demonstrated severe vessel irregularity in the bilateral cerebral arteries. Molecular genetic testing revealed a calreticulin mutation. To our knowledge, hemorrhagic stroke has been reported in only six other patients with ET, and this is the first report of hemorrhagic stroke in an ET patient with a calreticulin mutation. We review the current literature and discuss the possible underlying mechanisms.
与特发性血小板增多症（ET）相关的出血性脑卒中非常罕见。在此，我们报告了一例 33 岁女性 ET 病史 2 年，出现脑内和蛛网膜下腔出血。血管造影显示双侧大脑动脉严重血管不规则。分子遗传学检测发现钙网蛋白突变。据我们所知，仅有其他 6 例 ET 患者报告过出血性脑卒中，这是首例 ET 患者伴有钙网蛋白突变的出血性脑卒中报告。我们回顾了当前的文献并讨论了可能的潜在机制。
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