Department of Experimental Medical Science, Lund University, Lund, 22184, Sweden.
F1000Res. 2020 Jun 12;9:602. doi: 10.12688/f1000research.24173.2. eCollection 2020.
Biological systems are dynamic and display heterogeneity at all levels. Ubiquitous heterogeneity, here called for poikilosis, is an integral and important property of organisms and in molecules, systems and processes within them. Traditionally, heterogeneity in biology and experiments has been considered as unwanted noise, here poikilosis is shown to be the normal state. Acceptable variation ranges are called as lagom. Non-lagom, variations that are too extensive, have negative effects, which influence interconnected levels and once the variation is large enough cause a disease and can lead even to death. Poikilosis has numerous applications and consequences e.g. for how to design, analyze and report experiments, how to develop and apply prediction and modelling methods, and in diagnosis and treatment of diseases. Poikilosis-aware new and practical definitions are provided for life, death, senescence, disease, and lagom. Poikilosis is the first new unifying theory in biology since evolution and should be considered in every scientific study.
生物系统是动态的，在各个层次上都表现出异质性。普遍存在的异质性，在这里被称为斑驳性，是生物体及其内部分子、系统和过程的一个固有和重要特性。传统上，生物学和实验中的异质性被认为是不需要的噪声，而在这里，斑驳性被显示为正常状态。可接受的变化范围被称为拉格姆。非拉格姆，即变化范围过于广泛的情况，会产生负面影响，影响相互关联的层次，一旦变化足够大，就会导致疾病，甚至导致死亡。斑驳性有许多应用和后果，例如如何设计、分析和报告实验，如何开发和应用预测和建模方法，以及在疾病的诊断和治疗中。为生命、死亡、衰老、疾病和拉格姆提供了具有新视角和实际意义的定义。斑驳性是自进化以来生物学中的第一个新的统一理论，应该在每一项科学研究中加以考虑。
