Biotechnology Research Center and Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Basic Sciences, Faculty of Paramedicine Tabriz University of Medical Sciences, Tabriz, Iran.
Endocr Metab Immune Disord Drug Targets. 2021;21(7):1306-1311. doi: 10.2174/1871530320666200910113954.
Multiple sclerosis (MS), a disease of the central nervous system (CNS), is associated with damage to the myelin sheath of neurons. It is demonstrated that vitamin D deficiency plays an important role in the development of the disease. Binding of vitamin D to its specific nuclear receptors is a way to exert its function.
Possible correlation between the vitamin D receptor (VDR) gene and MS was evaluated in the Azeri population of Iran.
Different genotypes of the Bsml site were determined by using the PCR-RFLP method in 148 MS patients and 220 non-relative healthy controls.
In MS patients, genotype bb was significantly higher than the healthy controls (p<0.05). Additionally, most subjects of the MS group had been insufficiently exposed to sunlight before the age of 15 (p<0.001). Our findings indicated that the red meat intake in MS patients was significantly higher than the healthy controls (p<0.001). In addition, the healthy controls had appropriate dieting behaviors in comparison to MS patients (excessive intake of some foods) (p=0.0001).
In conclusion, genotype BB and sufficient exposure to sunlight before the age of 15 were the protective factors against MS. Although, excessive consumption of red meat and inappropriate dieting behaviors were predisposing factors to MS disease.
多发性硬化症（MS）是一种中枢神经系统（CNS）疾病，与神经元髓鞘损伤有关。研究表明，维生素 D 缺乏在疾病的发展中起着重要作用。维生素 D 与其特定核受体的结合是其发挥功能的一种方式。
在伊朗阿塞拜疆人群中评估维生素 D 受体（VDR）基因与 MS 之间的可能相关性。
采用 PCR-RFLP 法检测 148 例 MS 患者和 220 例非亲属健康对照者 Bsml 位点的不同基因型。
MS 患者的 bb 基因型明显高于健康对照组（p<0.05）。此外，MS 组大多数患者在 15 岁之前阳光照射不足（p<0.001）。我们的研究结果表明，MS 患者的红肉类摄入量明显高于健康对照组（p<0.001）。此外，与 MS 患者相比，健康对照组的饮食行为更为合理（某些食物摄入过多）（p=0.0001）。
综上所述，BB 基因型和 15 岁前充足的阳光照射是 MS 的保护因素。然而，过量摄入红肉类和不合理的饮食行为是 MS 疾病的易感因素。
