Sorbonne Université, INSERM, Institut Pierre-Louis d'Epidémiologie et de Santé Publique, AP-HP, Laboratoire de Parasitologie, Mycologie, Hôpital Pitié-Salpêtrière, Paris, France.
AP-HP, Centre National de Référence du Paludisme, Paris, France.
Euro Surveill. 2020 Sep;25(36). doi: 10.2807/1560-7917.ES.2020.25.36.1900579.
IntroductionMalaria is a notifiable disease in all European Union and European Economic Area countries except Belgium and France, where only autochthonous malaria is notifiable. Although morbidity caused by malaria has been assessed, little is known about mortality incidence.ObjectiveOur aim was to estimate the number of imported malaria-related deaths in hospital in metropolitan France.MethodsWe matched individual deaths reported between 1 January 2005 and 31 December 2014 to the French National Reference Centre for malaria (FNRCm) with malaria-related deaths from two other sources: the French National Registry on medical causes of death and the French national hospital discharge database. A capture-recapture method with log-linear modelling was used. Age, sex and place of death stratification were applied to remove heterogeneity.ResultsThe estimated malaria-related deaths in metropolitan France during the study period were 205 (95% confidence interval (CI): 191-219). The annual mean number of malaria-related deaths was estimated at 21 (95% CI: 19-22). The FNRCm malaria-related deaths surveillance had a 38% sensitivity (95% CI: 32-44). Among 161 in-hospital individual malaria-related deaths reported from three data sources, the sex ratio (male to female) was 2.6. Median age of the patients was 57 years, ranging from 1 to 89 years.ConclusionThe pertinent finding of this report is that malaria-related death records were significantly less complete [corrected] than case records. Therefore, data comparison of imported malaria morbidity and mortality between countries should imperatively be assessed using standard indicators weighted according to the completeness of health surveillance systems.
简介
在所有欧盟和欧洲经济区国家（比利时和法国除外），疟疾都是法定报告疾病，在这两个国家，只有输入性疟疾需要报告。尽管已经评估了疟疾引起的发病率，但对死亡率的了解甚少。
目的
我们的目的是估计法国大都市地区因疟疾住院的相关死亡人数。
方法
我们将 2005 年 1 月 1 日至 2014 年 12 月 31 日报告的个体死亡与法国国家疟疾参考中心（FNRCm）进行匹配，疟疾相关死亡来自另外两个来源：法国国家死因登记处和法国国家医院出院数据库。使用捕获-再捕获方法和对数线性模型进行分析。应用年龄、性别和死亡地点分层来消除异质性。
结果
在研究期间，估计法国大都市地区因疟疾死亡的人数为 205 人（95%置信区间（CI）：191-219）。估计每年因疟疾死亡的人数为 21 人（95% CI：19-22）。FNRCm 的疟疾相关死亡监测的敏感性为 38%（95% CI：32-44）。从三个数据源报告的 161 例疟疾住院相关死亡病例中，男女比例（男：女）为 2.6。患者的中位年龄为 57 岁，年龄范围为 1 至 89 岁。
结论
本报告的重要发现是，疟疾相关死亡记录的完整性明显低于病例记录。因此，在国家之间比较输入性疟疾发病率和死亡率时，应根据卫生监测系统的完整性使用加权标准指标进行数据比较。
