State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang, Guizhou 550025, People's Republic of China.
People's Republic of China; College of Chemistry and Chemical Engineering, Anshun University, Anshun, Guizhou 561000, China.
J Agric Food Chem. 2020 Oct 7;68(40):11039-11053. doi: 10.1021/acs.jafc.0c02376. Epub 2020 Sep 22.
Triflumezopyrim exemplifies a new class of mesoionic insecticides and has attracted increasing attention as a result of its unique structure, high level of insecticidal activity, new mechanisms of action, low toxicity toward non-target organisms, and environmental friendliness. It inhibits the nicotinic acetylcholine receptor and has high potency against sucking pests, including the brown planthopper (), which has developed serious resistance to conventional neonicotinoids and low cross-resistance to some newly developed neonicotinoids. This review focuses on the discovery, synthesis, structure-activity relationships, and mechanism of action of mesoionic insecticides. Finally, potential directions for the development of mesoionic insecticides are discussed.
三氟醚菊酯是一类新型的介离子杀虫剂，因其独特的结构、高效的杀虫活性、新颖的作用机制、对非靶标生物低毒性以及环境友好性而受到越来越多的关注。它抑制烟碱型乙酰胆碱受体，对包括褐飞虱（）在内的刺吸式害虫具有高效性，而褐飞虱对传统的新烟碱类杀虫剂已经产生了严重的抗性，并且对一些新开发的新烟碱类杀虫剂的交叉抗性较低。本文综述了介离子杀虫剂的发现、合成、构效关系和作用机制。最后，讨论了介离子杀虫剂的发展潜力。
