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一项使用背根神经节脉冲射频(DRG-PRF)连续治疗 42 例脊柱相关疼痛的真实世界证据。

A real-world evidence of a consecutive treatment of 42 spine-related pain using dorsal root ganglion-pulsed radiofrequency (DRG-PRF).

机构信息

Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Ph.D. Program in Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan.

出版信息

Clin Neurol Neurosurg. 2020 Oct;197:106186. doi: 10.1016/j.clineuro.2020.106186. Epub 2020 Aug 26.

Abstract

OBJECTIVES

Spine-related pain is oftentimes not managed satisfactorily by analgesic medications and physiotherapy. Pulsed radiofrequency targeting on dorsal root ganglion (DRG-PRF) is able to precisely relieve pain without permanent damage to nervous tissue. In this article, we provide a short-term result of DRG-PRF for spine-related pain.

PATIENTS AND METHODS

A retrospective chart review of a consecutive of 42 patients who underwent PRF between 2015-2016 was conducted. All patients had received pharmaceutical treatment or physiotherapy before PRF. The diagnoses included cervicogenic headache, cervicalgia, upper back, middle back and lower back pain with or without radiculopathy. All of them were treated with DRG-PRF according to corresponding segmental dermatomes. Preoperative and postoperative 1-week, 1-month and 3-month numerical rating scale (NRS) and the usage of analgesic medicines were recorded and analyzed.

RESULTS

The mean age was 56.9 ± 14.8 years and 50 % of them were men. Seventy-six percent of patients underwent PRF had their pain originated from cervical and lumbar spine. Sixty percent of PRF procedures were to treat new chronic pain (duration less than 6 months). The preoperative NRS was 7.6 ± 1.1; the postoperative 1-week, 1-month and 3-month NRS were 2.5 ± 2.1, 3.0 ± 2.4 and 3.2 ± 2.4, respectively. DRG-PRF provided significantly NRS decrease in spine-related pain (p < 0.001). DRG-PRF also significantly decrease and deescalate the usage of analgesic medicines at postoperative 3 months (p < 0.001). The drop of NRS from preoperative state to postoperative 1 week was more significant in new chronic pain than in established chronic pain group (1.6 ± 1.4 vs. 3.0 ± 2.2, p = 0.015), however, both groups achieved similar pain reduction at postoperative 3 months (3.1 ± 2.2 vs. 3.3 ± 2.7, p = 0.903). No permanent neurological sequela was found, except 2 patients (4.7 %) had transient paresthesia with mild motor weakness after PRF which resolved within hours spontaneously.

CONCLUSION

DRG-PRF significantly decrease NRS and decrease and deescalate the usage of analgesic medicines in post-procedure 3 months in spine-related pain patients. DRG-PRF is effective for both new chronic and established chronic pain, and offers similar pain reduction for patients with radicular or non-radicular pain.

摘要

目的

脊柱相关疼痛往往不能通过镇痛药物和物理疗法得到满意的治疗。针对背根神经节的脉冲射频(DRG-PRF)能够精确地缓解疼痛,而不会对神经组织造成永久性损伤。本文提供了 DRG-PRF 治疗脊柱相关疼痛的短期疗效。

方法

对 2015 年至 2016 年期间接受 PRF 治疗的 42 例连续患者进行回顾性图表分析。所有患者在接受 PRF 治疗前均接受过药物治疗或物理治疗。诊断包括颈源性头痛、颈痛、上背痛、中背痛和下背痛,伴或不伴神经根病。所有患者均根据相应的节段性皮区进行 DRG-PRF 治疗。记录和分析术前、术后 1 周、1 个月和 3 个月的数字评分量表(NRS)和镇痛药的使用情况。

结果

患者平均年龄为 56.9±14.8 岁,其中 50%为男性。76%的患者的疼痛源于颈椎和腰椎。60%的 PRF 治疗是为了治疗新的慢性疼痛(病程小于 6 个月)。术前 NRS 为 7.6±1.1;术后 1 周、1 个月和 3 个月的 NRS 分别为 2.5±2.1、3.0±2.4 和 3.2±2.4。DRG-PRF 显著降低了脊柱相关疼痛的 NRS(p<0.001)。DRG-PRF 还显著减少并降低了术后 3 个月的镇痛药使用量(p<0.001)。新发慢性疼痛组术后 1 周 NRS 下降幅度较稳定型慢性疼痛组更显著(1.6±1.4 比 3.0±2.2,p=0.015),但两组在术后 3 个月时均获得了相似的疼痛缓解(3.1±2.2 比 3.3±2.7,p=0.903)。除 2 例(4.7%)患者在 PRF 后出现短暂性感觉异常伴轻度运动无力外,未发现永久性神经后遗症,这些异常在数小时内自发缓解。

结论

DRG-PRF 可显著降低脊柱相关疼痛患者术后 3 个月的 NRS,并减少术后镇痛药的使用。DRG-PRF 对新发和稳定型慢性疼痛均有效,对根性或非根性疼痛患者均能获得相似的疼痛缓解。

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