锌：在胰腺生理学和疾病中的作用。
Zinc: Roles in pancreatic physiology and disease.
机构信息
Yale School of Medicine, Department of Internal Medicine and VA HealthCare System, CT, USA.
University of Pittsburgh, Department of Medicine, USA.
出版信息
Pancreatology. 2020 Oct;20(7):1413-1420. doi: 10.1016/j.pan.2020.08.016. Epub 2020 Sep 3.
Abstract
Zinc is an essential trace element. Deficiencies are frequently seen with gastrointestinal diseases, including chronic pancreatitis, nutritional deficiency, and reduced intestinal absorption. Additionally, reduced zinc levels have been linked to cellular changes associated with acute pancreatitis such as enhanced inflammation with increased macrophage activation and production of inflammatory cytokines such as IL-1β, impaired autophagy, and modulation of calcium homeostasis. Preliminary data suggest that zinc deficiency may lead to pancreatic injury in animal models. The purpose of this review is to explore the biologic effects of zinc deficiency that could impact pancreatic disease. MESH KEYWORDS: Malnutrition, inflammation, trace element.
摘要
锌是一种必需的微量元素。在胃肠道疾病中经常会出现缺锌的情况，包括慢性胰腺炎、营养缺乏和肠道吸收减少。此外，锌水平降低与急性胰腺炎相关的细胞变化有关，例如增强炎症，巨噬细胞激活增加，促炎细胞因子如 IL-1β 的产生增加，自噬受损，以及钙稳态的调节。初步数据表明，缺锌可能导致动物模型中的胰腺损伤。本综述的目的是探讨缺锌对胰腺疾病可能产生影响的生物学作用。ME SH 关键词：营养不良、炎症、微量元素。
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