Kettler A H, Bean S F, Duffy J O, Gammon W R
Department of Dermatology, Baylor College of Medicine, Houston.
Arch Dermatol. 1988 Jul;124(7):1083-7.
An 8-year-old girl presented with a generalized bullous eruption clinically resembling bullous pemphigoid or chronic bullous disease of childhood. Further study revealed immunopathologic findings seen in patients with epidermolysis bullosa acquisita or bullous systemic lupus erythematosus (SLE). Although she did not fulfill the American Rheumatism Association (Atlanta) criteria for SLE at her presentation, one year later she went on to do so. As well as being the youngest patient reported with bullous SLE, our patient is noteworthy because the bullous eruption was the initial manifestation of her SLE. Bullous SLE should be considered in the differential diagnosis of children presenting with generalized bullous eruptions.
一名8岁女孩出现全身性大疱性皮疹，临床症状类似于大疱性类天疱疮或儿童慢性大疱性疾病。进一步研究发现其免疫病理学表现与获得性大疱性表皮松解症或大疱性系统性红斑狼疮（SLE）患者所见相符。尽管她在初诊时未达到美国风湿病学会（亚特兰大）SLE诊断标准，但一年后达到了该标准。我们的患者不仅是报道的最年轻的大疱性SLE患者，而且值得注意的是，大疱性皮疹是她SLE的首发表现。对于出现全身性大疱性皮疹的儿童进行鉴别诊断时，应考虑大疱性SLE。
