Instuto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, CONICET, Mar del Plata, Argentina.
J Exp Bot. 2021 Mar 17;72(6):2125-2135. doi: 10.1093/jxb/eraa425.
Regulated cell death plays key roles during essential processes throughout the plant life cycle. It takes part in specific developmental programs and maintains homeostasis of the organism in response to unfavorable environments. Ferroptosis is a recently discovered iron-dependent cell death pathway characterized by the accumulation of lipid reactive oxygen species. In plants, ferroptosis shares all the main hallmarks described in other systems. Those specific features include biochemical and morphological signatures that seem to be conserved among species. However, plant cells have specific metabolic pathways and a high degree of metabolic compartmentalization. Together with their particular morphology, these features add more complexity to the plant ferroptosis pathway. In this review, we summarize the most recent advances in elucidating the roles of ferroptosis in plants, focusing on specific triggers, the main players, and underlying pathways.
细胞程序性死亡在植物生命周期的重要过程中发挥着关键作用。它参与特定的发育程序，并在应对不利环境时维持生物体的内稳态。铁死亡是一种最近发现的铁依赖性细胞死亡途径，其特征是脂质活性氧的积累。在植物中，铁死亡具有其他系统中描述的所有主要特征。这些特征包括生化和形态特征，似乎在物种间是保守的。然而，植物细胞具有特定的代谢途径和高度的代谢区室化。加上它们特殊的形态，这些特征为植物铁死亡途径增加了更多的复杂性。在这篇综述中，我们总结了阐明铁死亡在植物中的作用的最新进展，重点介绍了特定的触发因素、主要参与者和潜在途径。
