Preedy V R, Duane P, Peters T J
Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, U.K.
Alcohol Alcohol. 1988;23(2):151-4.
This paper responds to the recent article by Rao et al. (Alcohol and Alcoholism 21, 369-373, 1986) which suggested that the Lieber-De Carli liquid diet for chronic ethanol-feeding studies may not be suitable for the rat because of the changes in carbohydrate content. The viability of the Lieber-De Carli model was, therefore, re-examined. The content of the liquid diet was shown to be nutritionally adequate, when compared to a solid laboratory chow. However, rats on an alcohol feeding regime had sub-optimal growth rates, because of a reduction in the amount of liquid diet consumed. When compared to pair fed controls, rats fed the ethanol-containing diet showed marked changes in skeletal muscle. These observations are similar to those in man and we conclude that the use of the Lieber-De Carli feeding regime in experimental animals is a suitable means of investigating the mechanism of skeletal myopathy.
本文回应了饶等人最近发表的文章（《酒精与酒精中毒》21卷，第369 - 373页，1986年），该文章指出，由于碳水化合物含量的变化，用于慢性乙醇喂养研究的利伯 - 德卡利液体饮食可能不适用于大鼠。因此，重新审视了利伯 - 德卡利模型的可行性。与固体实验室饲料相比，液体饮食的成分显示出营养充足。然而，处于酒精喂养方案下的大鼠生长速率不理想，原因是所消耗的液体饮食量减少。与配对喂养的对照组相比，喂食含乙醇饮食的大鼠骨骼肌出现了明显变化。这些观察结果与人类的情况相似，我们得出结论，在实验动物中使用利伯 - 德卡利喂养方案是研究骨骼肌病机制的一种合适方法。
