Marway J S, Preedy V R, Peters T J
Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, London, U.K.
Alcohol Alcohol. 1990;25(4):401-6.
An investigation was made into the effects of ethanol feeding (36% of total calories) on skeletal muscle. From 7 to 42 days, muscle weights and protein and DNA contents of alcohol-treated rats were significantly lower (10-23%) than pair-fed controls (with glucose as 36% of total calories). Ethanol feeding markedly reduced muscle RNA content by 22-34%, when compared to controls. Muscle RNA content of ethanol-fed rats at 7, 14, 28 and 42 days of treatment was significantly lower than initial values (i.e. at 3 days) by 22-38%. Thus, ethanol feeding caused an initial net loss and thereafter a reduction in the rate of accretion of RNA. The marked and sustained loss in the muscle protein synthetic apparatus may be a precipitating event in the development of experimental skeletal muscle myopathy.
研究了给予乙醇（占总热量的36%）对骨骼肌的影响。在7至42天期间，经酒精处理的大鼠的肌肉重量、蛋白质和DNA含量显著低于配对喂养的对照组（以葡萄糖作为总热量的36%），低10 - 23%。与对照组相比，给予乙醇使肌肉RNA含量显著降低22 - 34%。在治疗7、14、28和42天的给予乙醇的大鼠的肌肉RNA含量比初始值（即3天时）显著降低22 - 38%。因此，给予乙醇导致RNA最初的净损失，随后RNA积累速率降低。肌肉蛋白质合成装置的显著且持续的损失可能是实验性骨骼肌肌病发展过程中的一个促发事件。
