School of Pharmacy, Southwest University, Chongqing, China.
Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
J Ethnopharmacol. 2021 Mar 1;267:113383. doi: 10.1016/j.jep.2020.113383. Epub 2020 Sep 9.
Although Traditional Chinese Medicine (TCM) has a millennia-long history of treating human brain disorders, its complex multi-target mechanisms of action remain poorly understood. Animal models are currently widely used to probe the effects of various TCMs on brain and behavior. The zebrafish (Danio rerio) has recently emerged as a novel vertebrate model organism for neuroscience research, and is increasingly applied for CNS drug screening and development.
As zebrafish models are only beginning to be applied to studying TCM, we aim to provide a comprehensive review of the TCM effects on brain and behavior in this fish model species.
A comprehensive search of published literature was conducted using biomedical databases (Web of Science, Pubmed, Sciencedirect, Google Scholar and China National Knowledge Internet, CNKI), with key search words zebrafish, brain, Traditional Chinese Medicine, herbs, CNS, behavior.
We recognize the developing utility of zebrafish for studying TCM, as well as outline the existing model limitations, problems and challenges, as well as future directions of research in this field.
We demonstrate the growing value of zebrafish models for studying TCM, aiming to improve our understanding of TCM' therapeutic mechanisms and potential in treating brain disorders.
尽管中医药（TCM）在治疗人类大脑疾病方面已有数千年的历史，但对其复杂的多靶点作用机制仍知之甚少。目前，动物模型被广泛用于探究各种 TCM 对大脑和行为的影响。斑马鱼（Danio rerio）最近已成为神经科学研究的新型脊椎动物模式生物，并越来越多地应用于中枢神经系统药物筛选和开发。
由于斑马鱼模型仅开始应用于 TCM 的研究，我们旨在为该鱼类模型物种中 TCM 对大脑和行为的影响提供全面的综述。
使用生物医学数据库（Web of Science、Pubmed、Sciencedirect、Google Scholar 和中国国家知识互联网，CNKI）对已发表的文献进行全面检索，关键词包括斑马鱼、大脑、中医药、草药、中枢神经系统、行为。
我们认识到斑马鱼在研究 TCM 方面的应用潜力不断增加，同时概述了现有模型的局限性、问题和挑战，以及该领域未来的研究方向。
我们展示了斑马鱼模型在研究 TCM 方面的日益重要性，旨在提高我们对 TCM 治疗机制及其治疗大脑疾病潜力的理解。
