First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic; Central European Institute of Technology (CEITEC), Masaryk University, Brain and Mind Research Program, Brno, Czech Republic.
Central European Institute of Technology (CEITEC), Masaryk University, Brain and Mind Research Program, Brno, Czech Republic.
Epilepsy Behav. 2020 Nov;112:107409. doi: 10.1016/j.yebeh.2020.107409. Epub 2020 Sep 9.
We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe.
High-density electroencephalography (EEG) was recorded during the paradigm from nineteen patients with epilepsy with hippocampal sclerosis (HS) and ten healthy controls (HCs). Scalp data were reconstructed into the source space, and FC was computed. Correlating with the neuropsychological data, possible compensatory mechanisms were investigated.
Significant changes were found in the FC of regions outside the epileptogenic network, particularly in the attentional network. These changes were more widespread in left TLE (LTLE). There were no significant differences in task performance (accuracy, time response) in comparison with HCs, implying that there must be some mechanism reducing the impact of connectivity changes on brain functions. When correlated with neuropsychological data, we found stronger compensatory mechanisms in right TLE (RTLE).
Our findings confirm the hypothesis that LTLE is the more pervasive form of the disease. Even though the network alterations in TLE are severe, some mechanisms reduce the impact of epilepsy on cognitive functions; these mechanisms are more potent in RTLE. We also suggest that there are maladaptive mechanisms in LTLE.
我们研究了颞叶癫痫（TLE）患者认知任务相关的功能连接（FC）。使用视觉三刺激范式（VTSP），我们研究了认知大网络以及 TLE 对颞叶以外连接的影响。
在范式期间，从 19 名伴有海马硬化（HS）的癫痫患者和 10 名健康对照（HC）中记录高密度脑电图（EEG）。头皮数据被重建到源空间，并计算了 FC。通过与神经心理学数据相关联，研究了可能的代偿机制。
在癫痫网络外的区域的 FC 中发现了显著的变化，特别是在注意力网络中。这些变化在左颞叶癫痫（LTLE）中更为广泛。与 HC 相比，在任务表现（准确性、时间反应）方面没有显著差异，这意味着一定有某种机制减轻了连接变化对大脑功能的影响。当与神经心理学数据相关联时，我们发现右颞叶癫痫（RTLE）中有更强的代偿机制。
我们的发现证实了 LTLE 是更普遍形式的疾病的假设。尽管 TLE 中的网络改变是严重的，但一些机制减轻了癫痫对认知功能的影响；这些机制在 RTLE 中更为有效。我们还认为 LTLE 中存在适应不良的机制。
