First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic; Central European Institute of Technology (CEITEC), Masaryk University, Brain and Mind Research Program, Brno, Czech Republic.
Central European Institute of Technology (CEITEC), Masaryk University, Brain and Mind Research Program, Brno, Czech Republic.
Epilepsy Behav. 2021 Sep;122:108196. doi: 10.1016/j.yebeh.2021.108196. Epub 2021 Jul 10.
We analyzed the impact of temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) on functional connectivity (FC) between mesiotemporal structures. Functional connectivity modifications related to word retrieval were investigated.
High-density EEG of 21 patients with TLE with HS (12 left TLE and 9 right TLE) and 10 healthy controls (HCs) were recorded during a verbal subsequent memory paradigm. Electroencephalography data were reconstructed into the source space and FC was calculated from the source activity of regions of interest.
A significant decrease in FC between the right- and left-sided mesiotemporal structures in TLE was observed. The decrease was significant only with words that were correctly recognized. The decrease in interhemispheric FC between mesiotemporal structures was found in the 8- to 20-Hz frequency range in both left and right TLE.
The decreased FC between the mesiotemporal structures in TLE is a condition for successful performance of a memory retrieval task. The successful memory retrieval in TLE is related to functional segregation of lesional from nonlesional mesiotemporal structures. This decrease was absent in non-successful responses.
我们分析了伴有海马硬化的颞叶癫痫（TLE）对间脑结构之间功能连接（FC）的影响。研究了与单词检索相关的功能连接变化。
在一项口头后续记忆范式中，对 21 例伴有海马硬化的 TLE 患者（12 例左侧 TLE 和 9 例右侧 TLE）和 10 例健康对照（HCs）进行了高密度 EEG 记录。将脑电图数据重建到源空间，并从感兴趣区域的源活动中计算 FC。
在 TLE 中观察到右侧和左侧间脑结构之间 FC 的显著降低。仅在正确识别的单词中观察到这种降低。在左、右侧 TLE 中，在 8 至 20 Hz 的频率范围内，发现间脑结构之间的半球间 FC 降低。
TLE 中间脑结构之间 FC 的降低是成功完成记忆检索任务的条件。TLE 中的成功记忆检索与损伤和非损伤间脑结构的功能分离有关。在非成功反应中，这种降低并不存在。
