Shingai R, Ebina Y
Department of Pharmacology, School of Medicine, Department of Electrical Faculty of Engineering, Yamaguchi University, Ube, Japan.
Brain Res. 1988 May 10;448(1):198-203. doi: 10.1016/0006-8993(88)91120-1.
Ionic currents induced by glutamate, kainate, quisqualate, and N-methyl-D-aspartate (NMDA) in cultured septal neurons were analyzed by fluctuations analysis. The power spectrum (PWS) of NMDA current fluctuations always fitted a single Lorentzian. PWSs of the other agonists fitted the sum of two Lorentzians; however, the slopes of PWSs became larger and the PWSs became closer to single Lorentzians as the number of drug application increased. This may be explained in such a way that, in multiple conductance channels activated by these agonists, the high frequency component decreases the gating activity in later recordings, whereas the low frequency component keeps its gating kinetics.
