Garthwaite G, Yamini B, Garthwaite J
Department of Veterinary Physiology and Pharmacology, University of Liverpool, U.K.
Brain Res. 1987 Dec 1;433(2):288-92. doi: 10.1016/0165-3806(87)90034-4.
Depolarizing responses of Purkinje and granule cells to excitatory amino acid receptor agonists were recorded from rat cerebellar slices at various stages of postnatal maturation using a gap technique. No major developmental changes in relative potency or efficacy of kainate and quisqualate were observed. However, Purkinje and granule neurones both became less responsive to N-methyl-D-aspartate (NMDA) with age, most dramatically so between 14 and 21 days. This transient chemosensitivity to NMDA may reflect a special role of the NMDA receptor system in cerebellar development.
采用缝隙连接技术，在出生后不同发育阶段的大鼠小脑切片上记录了浦肯野细胞和颗粒细胞对兴奋性氨基酸受体激动剂的去极化反应。未观察到海藻酸和喹啉酸的相对效价或效能有重大发育变化。然而，浦肯野神经元和颗粒神经元对N-甲基-D-天冬氨酸（NMDA）的反应均随年龄增长而降低，在14至21天之间最为显著。这种对NMDA的短暂化学敏感性可能反映了NMDA受体系统在小脑发育中的特殊作用。
