University of São Paulo, São Paulo, Brazil.
Federal University of Espirito Santo, Espirito Santo, Brazil.
Eur J Neurol. 2021 Jan;28(1):71-80. doi: 10.1111/ene.14532. Epub 2020 Oct 12.
Most evidence for the association between ideal vascular health (IVH) and cognitive performance comes from high income countries. The aim was to investigate this association in the Brazilian Longitudinal Study of Adult Health.
Cognition was assessed using the word list, verbal fluency and trail making tests. The IVH score included ideal metrics for body mass index, smoking, physical activity, diet, blood pressure, fasting glucose and total cholesterol. Poor, intermediate and optimal health were characterized in those presenting 0-2, 3-4, 5-7 ideal metrics, respectively. To determine the association between IVH score and cognitive performance, linear regression models adjusted for age, sex, education, race, alcohol use, depression and thyroid function were used.
In 12 271 participants, the mean age was 51.3 ± 8.9 years, 54% were women, 57% White and 53% had poor vascular health. Participants with intermediate (β = 0.064, 95% confidence interval 0.033; 0.096) and optimal health (β = 0.108, 95% confidence interval 0.052; 0.164) had better global cognitive Z-scores. In addition, interactions of IVH score with age, education and race were found, suggesting a better cognitive performance with higher IVH in older adults, Black/Brown participants and those with lower levels of education.
Ideal vascular health was associated with better cognitive performance. Older, Black/Brown and low-educated participants had better cognition in the presence of higher IVH scores.
大多数关于理想血管健康（IVH）与认知表现之间关联的证据来自高收入国家。本研究旨在巴西成人健康纵向研究中调查这种关联。
使用单词列表、言语流畅性和连线测试评估认知能力。IVH 评分包括身体质量指数、吸烟、身体活动、饮食、血压、空腹血糖和总胆固醇的理想指标。分别将存在 0-2、3-4、5-7 个理想指标的人群归类为健康状况差、中等和良好。为了确定 IVH 评分与认知表现之间的关联，使用调整了年龄、性别、教育程度、种族、饮酒、抑郁和甲状腺功能的线性回归模型进行分析。
在 12 271 名参与者中，平均年龄为 51.3±8.9 岁，54%为女性，57%为白种人，53%血管健康状况较差。具有中等（β=0.064，95%置信区间 0.033；0.096）和良好（β=0.108，95%置信区间 0.052；0.164）IVH 的参与者的整体认知 Z 评分更高。此外，还发现了 IVH 评分与年龄、教育程度和种族之间的交互作用，表明在年龄较大、黑人和棕色人种以及教育程度较低的参与者中，IVH 评分较高与认知表现较好相关。
理想的血管健康与更好的认知表现相关。年龄较大、黑人和棕色人种以及教育程度较低的参与者在 IVH 评分较高时认知表现更好。
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