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Epidemiology of neurocognitive disorders in adults from urban-marginalized areas: a door-to-door population-based study in Puente Piedra, Lima, Peru.城市边缘地区成年人神经认知障碍的流行病学:秘鲁利马 Puente Piedra 的一项基于人群的入户研究。
Front Public Health. 2023 Oct 19;11:1228008. doi: 10.3389/fpubh.2023.1228008. eCollection 2023.
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Multivariate word properties in fluency tasks reveal markers of Alzheimer's dementia.在流畅性任务中的多元词汇特性揭示了阿尔茨海默病的标志物。
Alzheimers Dement. 2024 Feb;20(2):925-940. doi: 10.1002/alz.13472. Epub 2023 Oct 12.
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Toolkit to Examine Lifelike Language (TELL): An app to capture speech and language markers of neurodegeneration.用于评估真实语言的工具包(TELL):一款用于捕捉神经退行性变的言语和语言标志物的应用程序。
Behav Res Methods. 2024 Apr;56(4):2886-2900. doi: 10.3758/s13428-023-02240-z. Epub 2023 Sep 27.
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Risk factors related to population diversity and disparity determine healthy aging.与人口多样性和差异相关的风险因素决定了健康老龄化。
Nat Med. 2023 Sep;29(9):2183-2184. doi: 10.1038/s41591-023-02531-0.
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Factors associated with healthy aging in Latin American populations.与拉丁美洲人群健康老龄化相关的因素。
Nat Med. 2023 Sep;29(9):2248-2258. doi: 10.1038/s41591-023-02495-1. Epub 2023 Aug 10.
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Speech and language markers of neurodegeneration: a call for global equity.神经退行性病变的言语和语言标志物:呼吁全球公平。
Brain. 2023 Dec 1;146(12):4870-4879. doi: 10.1093/brain/awad253.
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A task force for diagnosis and treatment of people with Alzheimer's disease in Latin America.拉丁美洲阿尔茨海默病患者诊断与治疗特别工作组。
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Alzheimer's disease drug development pipeline: 2023.2023年阿尔茨海默病药物研发进展
Alzheimers Dement (N Y). 2023 May 25;9(2):e12385. doi: 10.1002/trc2.12385. eCollection 2023 Apr-Jun.
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Alzheimers Dement. 2023 Sep;19(9):4046-4060. doi: 10.1002/alz.13101. Epub 2023 May 19.
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Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man.载脂蛋白 E 基因型与阿尔茨海默病风险:系统评价和荟萃分析
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拉丁美洲痴呆症研究、诊断和护理的进展:2023 年阿尔茨海默病协会国际会议在墨西哥城卫星研讨会的要点。

Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City.

机构信息

Laboratorio de Demencias del Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, CDMX, México.

Department of Neurology, Cognitive and Behavioral Group, University of Sao Paulo, São Paulo, São Paulo, Brazil.

出版信息

Alzheimers Dement. 2024 Jul;20(7):5009-5026. doi: 10.1002/alz.13850. Epub 2024 May 27.

DOI:10.1002/alz.13850
PMID:38801124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11247679/
Abstract

INTRODUCTION

While Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics, and care.

METHODS

In 2023, the Alzheimer's Association hosted its eighth satellite symposium in Mexico, highlighting emerging dementia research, priorities, and challenges within LatAm.

RESULTS

Significant initiatives in the region, including intracountry support, showcased their efforts in fostering national and international collaborations; genetic studies unveiled the unique genetic admixture in LatAm; researchers conducting emerging clinical trials discussed ongoing culturally specific interventions; and the urgent need to harmonize practices and studies, improve diagnosis and care, and use affordable biomarkers in the region was highlighted.

DISCUSSION

The myriad of topics discussed at the 2023 AAIC satellite symposium highlighted the growing research efforts in LatAm, providing valuable insights into dementia biology, genetics, epidemiology, treatment, and care.

摘要

简介

随着拉丁美洲(LatAm)人口的快速老龄化,痴呆症负担日益加重,但该地区在痴呆症研究、诊断和护理方面的代表性仍然不足。

方法

2023 年,阿尔茨海默病协会在墨西哥举办了第八届卫星研讨会,重点介绍了拉丁美洲新兴的痴呆症研究、优先事项和挑战。

结果

该地区的重要举措,包括国内支持,展示了他们在促进国家和国际合作方面的努力;遗传研究揭示了拉丁美洲独特的遗传混合;正在进行新兴临床试验的研究人员讨论了正在进行的文化特异性干预措施;迫切需要协调该地区的实践和研究,改善诊断和护理,并使用负担得起的生物标志物。

讨论

在 2023 年 AAIC 卫星研讨会上讨论的众多主题强调了拉丁美洲日益增长的研究努力,为痴呆症生物学、遗传学、流行病学、治疗和护理提供了有价值的见解。